Author

P. ROZARIO

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

F. L. Zhong· 3 shared C. BONNARD· 2 shared G. A. TOH· 2 shared K. S. ROBINSON· 2 shared A. C. Vind· 1 shared C. K. LIM· 1 shared C. LIM· 1 shared C. R. HARAPAS· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

F. L. Zhong

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3 papers

Recent·Most cited

Mechanistic basis for nigericin-induced NLRP1 inflammasome activation in human epithelial cells

F. L. Zhong, P. Rozario, M. Pinilla, A. C. Vind, K. Robinson, T. Gee Ann, M. Jasrie Firdaus, J. Francisco Martinez, L. Zhewang, S. Bekker-Jensen, E. Meunier

This study identifies the mechanism by which nigericin activates the NLRP1 inflammasome in human epithelial cells through potassium efflux and ribotoxic stress response.

bioRxiv · Jun 23, 2023 · PreprintImmunology

Corynebacterium diphtheriae causes keratinocyte-intrinsic ribotoxic stress and NLRP1 inflammasome activation in a model of cutaneous diphtheria

K. S. ROBINSON, G. A. TOH, M. J. FIRDAUS, K. C. THAM, P. ROZARIO, C. LIM, Y. X. TOH, Z. H. LAU, S. C. BINDER, J. MAYER, C. BONNARD, F. I. SCHMIDT, J. A. COMMON, F. L. ZHONG

This paper shows that Corynebacterium diphtheriae toxin activates NLRP1 inflammasome and pyroptosis in keratinocytes via ribotoxic stress response pathways.

bioRxiv · Jan 16, 2023 · PreprintImmunology

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

K. S. ROBINSON, G. A. TOH, P. ROZARIO, S. BAYAT, Z. SUN, S. BAUERNFRIED, R. NADKARNI, C. R. HARAPAS, C. K. LIM, W. CHU, K. Y. TAN, C. BONNARD, R. SOBOTA, J. E. CONNOLLY, S. L. MASTERS, , F. L. Zhong

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

bioRxiv · Jan 24, 2022 · PreprintImmunology