Author

C. K. Lim

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

F. L. Zhong· 2 shared G. A. TOH· 2 shared A. P. Chilver· 1 shared A. Perrin· 1 shared A. Ruszkiewicz· 1 shared B. M. Tran· 1 shared B. Reversade· 1 shared B. V. Au· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersImmunology

F. L. Zhong

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Human Liver Organoids as a Patient-derived Model for HBV Infection and Cellular Response

C. K. Lim, O. Romeo, A. P. Chilver, B. M. Tran, D. Flanagan, E. N. Kirby, J. Breen, E. Vincan, N. Warner, E. M. McCartney, M. Van der Hoek, A. Ruszkiewicz, E. Tse, M. R. Beard

This paper develops a liver organoid model to study HBV infection and antiviral responses, showing it supports the full HBV lifecycle and can assess drug and immunomodulator effects.

bioRxiv · Oct 20, 2022 · PreprintMicrobiology

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

K. S. ROBINSON, G. A. TOH, P. ROZARIO, S. BAYAT, Z. SUN, S. BAUERNFRIED, R. NADKARNI, C. R. HARAPAS, C. K. LIM, W. CHU, K. Y. TAN, C. BONNARD, R. SOBOTA, J. E. CONNOLLY, S. L. MASTERS, , F. L. Zhong

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

bioRxiv · Jan 24, 2022 · PreprintImmunology

The novel conserved NAD+ binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

R. Foo, V. Do, N. Tulsian, W. Tan, Z. Li, L. Cheng, M. I. Autio, W. Tan, Z. Tiang, A. Perrin, J. Ching, C. Ramachandra, C. K. Lim, D. Hausenloy, C. Drum, , M. Lee

bioRxiv · Oct 24, 2021 · PreprintCell Biology

Integrative genome-scale metabolic modeling reveals versatile metabolic strategies for methane utilization in Methylomicrobium album BG8

J. C. Villada, M. F. Duran, C. K. Lim, L. Y. Stein, P. K. H. Lee

This study constructs a genome-scale metabolic model for Methylomicrobium album BG8 and integrates experimental data to analyze metabolic strategies for methane utilization and excretion.

bioRxiv · Mar 21, 2021Microbiology

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

K. Robinson, D. E. T. Teo, K. S. Tan, G. A. Toh, H. H. Ong, C. K. Lim, K. Lay, B. V. Au, T. S. Lew, J. J. H. Chu, V. T. K. Chow, D. Y. Wang, F. L. Zhong, B. Reversade

The paper identifies enteroviral 3C proteases as the first cognate PAMP ligand for human NLRP1, showing they trigger inflammasome activation and airway inflammation.

bioRxiv · Oct 14, 2020 · PreprintImmunology