R. Sobota

TDP43 aggregation at ER-exit sites impairs ER-to-Golgi transport

The paper identifies TDP43 aggregation at ER-exit sites as a cause of impaired ER-to-Golgi transport in ALS.

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development

This study identifies falcilysin as a target of anti-malaria drugs and reveals a shared inhibitory pocket that could guide new drug development.

The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state

This paper identifies and characterizes two distinct developmental forms of Orientia tsutsugamushi, intracellular and extracellular bacteria, showing differences in morphology, protein expression, and entry mechanisms into host cells.

BRAWNIN: A sORF-encoded Peptide Essential for Vertebrate Mitochondrial Complex III Assembly

The paper identifies BRAWNIN, a sORF-encoded peptide critical for vertebrate mitochondrial complex III assembly, showing its role in oxidative phosphorylation and metabolic function.

Dual RNA-seq provides insight into the biology of the neglected intracellular human pathogen Orientia tsutsugamushi

The paper uses dual RNA-seq to study the transcriptional architecture and host-pathogen interactions of Orientia tsutsugamushi, identifying antisense regulation and strain-specific immune responses.