J. T. Poirier

This study shows KEAP1 mutations in lung adenocarcinoma lead to immune evasion by reducing dendritic cell and T cell responses, contributing to immunotherapy resistance.

The paper identifies molecular mechanisms of neuroendocrine transformation in lung cancer using multi-omic analysis of tumors and clinical samples.

The paper profiles single-cell transcriptomes of SCLC subtypes to identify novel tumor and myeloid subpopulations and their associations with metastasis and immune microenvironment changes.

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

This study develops a CRISPR-Cas9 lentiviral platform for genome editing of patient-derived xenografts to analyze genetic dependencies and drug resistance mechanisms in vivo.