Author

M. P. Zafra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

L. E. Dow· 4 shared S. Goswami· 4 shared A. Katti· 2 shared B. J. Diaz· 2 shared M. Foronda· 2 shared T. Han· 2 shared A. P. Kadina· 1 shared A. Wuest· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCancer Biology

L. E. Dow

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rapid generation of precision preclinical cancer models using regulatable in vivo base editing

A. Katti, M. Foronda, J. Zimmermann, M. P. Zafra, S. Goswami, E. E. Gardner, B. J. Diaz, J. M. Simon, A. Wuest, W. Luan, M. T. C. Fernandez, A. P. Kadina, J. A. Walker, K. Holden, F. J. Sanchez-Rivera, , L. E. Dow

This study develops a murine system for temporal and regulatable in vivo cytosine base editing to rapidly generate preclinical cancer models with specific SNVs.

bioRxiv · Aug 3, 2022 · PreprintCancer Biology

Lineage reversion drives WNT independence in intestinal cancer

T. Han, S. Goswami, Y. Hu, F. Tang, M. P. Zafra, C. Murphy, Z. Cao, J. T. Poirier, E. Khurana, O. Elemento, J. F. Hechtman, R. Yeager, L. E. Dow

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

bioRxiv · Jan 22, 2020Cancer Biology

GO: A functional reporter system to identify and enrich base editing activity

A. Katti, M. Foronda, J. Zimmerman, B. J. Diaz, M. P. Zafra, S. Goswami, L. E. Dow

The paper introduces a functional reporter system called GO to identify and enrich base editing activity in cells with high sensitivity and specificity.

bioRxiv · Dec 3, 2019Bioengineering

An in vivo KRAS allelic series reveals distinct phenotypes of common oncogenic variants

M. P. Zafra, D. Alonso-Curbelo, S. Goswami, E. M. Schatoff, T. Han, J. E. Wilkinson, L. E. Dow

The paper creates KRAS mutant mouse models to study how different oncogenic variants affect tumor development and therapy response in vivo.

bioRxiv · Nov 20, 2019Cancer Biology