Multiscale mechanisms driving tissue rupture by invading cells
S. K. Wu, F. Sun, C. Z. Ho, Y. Lou, C. B.-X. Huang, M. H. Nai, J. Xiao, M. Shagirov, J. F. L. Chin, D. Lim, S. Verma, D. S. Tan, P. Marcq, A. Yap, C. T. Lim, , B. C. Low
This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.
bioRxiv · Sep 25, 2023Cell Biology