P. Marcq

Mechanical characterization of regenerating Hydra tissue spheres

This study characterizes the mechanical properties of Hydra vulgaris tissue spheres using microaspiration and simulations, revealing three distinct mechanical behaviors during regeneration.

Multiscale mechanisms driving tissue rupture by invading cells

This study identifies a mechanism where invading cells and tissue barriers coordinate to rupture barriers through intercellular adhesions and subcellular contractility, challenging existing models of collective invasion.

Mechanical stress driven by rigidity sensing governs epithelial stability

The paper shows that substrate stiffness drives mechanical switches in epithelial monolayers, leading to stochastic failure through topological defects.

Enhanced RhoA signaling stabilizes E-cadherin in migrating epithelial monolayers.

The paper shows that RhoA signaling at adherens junctions stabilizes E-cadherin during epithelial migration by increasing junctional contractility and mechanical tension.

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

Myosin II isoforms play distinct roles in adherens junction biogenesis

This study identifies distinct roles of myosin II isoforms in adherens junction biogenesis, showing NMIIA provides mechanical force for junction maintenance while NMIIB facilitates E-cadherin clustering and anisotropic stress.

Sustained oscillations of epithelial cell sheets

This study identifies a novel mode of collective oscillations in epithelial cell sheets under confinement, showing that oscillatory motion drives cellular movements and is regulated by confinement dimensions and force transmission.