Author

J. Fransen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Organism:human· 1

Frequent Co-Authors

A. B. Houtsmuller· 1 shared A. Cambi· 1 shared A. Meijer· 1 shared A. Messent· 1 shared B. Joosten· 1 shared B. Lelli· 1 shared B. Oldenburg· 1 shared B. Weigelin· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCell Biology

A. B. Houtsmuller

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4 papers

Recent·Most cited

Functional basis for calmodulation of the TRPV5 calcium channel

S. R. Roig, N. Thijssen, M. van Erp, J. Fransen, J. Hoenderop, J. van der Wijst

This study characterizes the dynamic regulation of TRPV5 by calmodulin using advanced microscopy and biochemical assays, revealing a 1:2 stoichiometry and lobe-specific interactions.

bioRxiv · Feb 16, 2021 · PreprintCell Biology

Catestatin regulates the colonic mucus layer in inflammatory bowel disease

E. Muntjewerff, L. Lutter, K. Tang, M. Kea-te Lindert, J. Fransen, B. Oldenburg, S. K. Mahata, G. van den Bogaart

This study shows that catestatin (CST) regulates the colonic mucus layer in IBD, with CST levels elevated in IBD patients and CST-KO mice showing increased mucus thickness.

bioRxiv · Feb 9, 2021 · PreprintImmunology

Glycocalyx-mediated Cell Adhesion and Migration

S. Schmidt, B. Weigelin, J. te Riet, V. te Boekhorst, M. te Lindert, M. Wijers-Rouw, B. Lelli, L. Rognoni, M. Krause-Vortmeyer, A. Messent, L. Bracci, K. E. Gottschalk, S. Kissler, M. Humphries, D. J. Lefeber, , P. Friedl

This study shows the glycocalyx enables cell adhesion and amoeboid migration through nanoscale interactions and mechano-coupling, independent of integrin function.

bioRxiv · Jun 12, 2020 · PreprintCell Biology

Modular actin nano-architecture enables podosome protrusion and mechanosensing

K. van den Dries, L. Nahidiazar, J. A. Slotman, M. B. M. Meddens, E. Pandzic, B. Joosten, M. Ansems, J. Schouwstra, A. Meijer, R. Steen, M. Wijers, J. Fransen, A. B. Houtsmuller, P. W. Wiseman, K. Jalink, A. Cambi

This study identifies the modular actin nano-architecture of podosomes, showing how different actin modules enable protrusion and mechanosensing on varying substrate stiffness.

bioRxiv · Mar 20, 2019Cell Biology