S. Mosalaganti

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Structure of the human systemic RNAi defective transmembrane protein 1 (hSIDT1) reveals the conformational flexibility of its lipid binding domain

The paper reports the structure of hSIDT1, revealing its lipid binding domain's conformational flexibility and structural features.

Structure of the human heparan-α-glucosaminide N-acetyltransferase (HGSNAT)

This study determines the high-resolution structure of HGSNAT-acetyl-CoA complex using cryo-EM and maps MPS IIIC mutations to elucidate dysfunction mechanisms.

Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase

The paper introduces a method to produce graphene-coated grids for cryo-EM and demonstrates their use in determining the structure of sMMOH at high resolution.

3D super-resolution fluorescence microscopy maps the variable molecular architecture of the Nuclear Pore Complex

The paper uses 3D super-resolution microscopy and computational methods to map the 3D structure of the Nuclear Pore Complex in human cells, revealing variable conformations of its subunits.

In situ architecture of the algal nuclear pore complex

This study reports the in situ architecture of the algal nuclear pore complex in Chlamydomonas reinhardtii and compares it to the human NPC, revealing structural variations between species.