T. A. Bell

Ancestral sequence reconstruction of the Mic60 Mitofilin domain reveals residues supporting respiration in yeast

This study uses ancestral sequence reconstruction to identify residues in the Mitofilin domain of Mic60 that support respiration in yeast.

Prominin 1 and Tweety Homology 1 both induce extracellular vesicle formation

This study shows that Prom1 and Ttyh1 both induce extracellular vesicle formation, with Ttyh1 producing more tubulated vesicles and showing stronger cholesterol binding.

A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation

The paper presents cryo-EM structures of E. coli ClpXP, showing that a closed axial channel in ClpX enhances degradation specificity by preventing non-specific substrate entry.

A Multitrait Locus Regulates Sarbecovirus Pathogenesis

The paper identifies a multitrait locus on mouse Chromosome 9 that regulates SARS-CoV, SARS-CoV-2, and bat sarbecovirus disease severity, with candidate genes CCR9 and CXCR6.

A natural fusion of flavodiiron, rubredoxin, and NADH:rubredoxin oxidoreductase domains is the highly efficient water-forming oxidase of T. vaginalis

This study identifies a unique fusion protein in T. vaginalis that efficiently catalyzes oxygen reduction to water using NADH, providing structural and functional insights into its redox system.

Common Mechanism of SARS-CoV and SARS-CoV-2 Pathogenesis across Species

The paper identifies host susceptibility loci for SARS-CoV and SARS-CoV-2 using GWAS and Collaborative Cross datasets, validating CCR9 as a key regulator of severe disease outcomes across species.

ClpAP proteolysis does not require rotation of the ClpA unfoldase relative to ClpP

This study shows that ClpA does not need to rotate relative to ClpP for proteolysis, though some flexibility may aid function.

Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

The paper presents cryo-EM structures of ClpXP bound to the ssrA degron, revealing how it recognizes and unfolds ssrA-tagged substrates through a multistep process.

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

This study presents cryo-EM structures of the E. coli ClpXP protease complex, revealing how ClpX interacts with ClpP and substrates, and proposes models for its ATP-dependent proteolytic mechanism.

Functionally overlapping variants control TB susceptibility in Collaborative Cross mice

The paper identifies multiple genetic loci associated with tuberculosis susceptibility in Collaborative Cross mice, including a loss-of-function mutation in Itgal that impairs T cell recruitment.