Author

S. M. Grimes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Assay:spatial transcriptomics· 2

Frequent Co-Authors

A. Sathe· 4 shared X. Bai· 4 shared A. Su· 2 shared B. Lee· 2 shared C. Ayala· 2 shared G. Poultsides· 2 shared H. Ji· 2 shared H. P. Ji· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersCancer Biology

A. Sathe

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4 papers

Recent·Most cited

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

R. J. Huang, I. A. Wichmann, A. Su, A. Sathe, M. V. Shum, S. M. Grimes, R. Meka, A. Almeda, X. Bai, J. Shen, Q. Nguyen, M. R. Amieva, J. H. Hwang, H. Ji

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

bioRxiv · Sep 20, 2023Cancer Biology

GITR and TIGIT immunotherapy provokes divergent multi-cellular responses in the tumor microenvironment of gastrointestinal cancers

A. Sathe, C. Ayala, X. Bai, S. M. Grimes, B. Lee, C. Kin, A. Shelton, G. Poultsides, H. Ji

The paper examines GITR and TIGIT immunotherapies in gastrointestinal cancers using ex vivo cultures and single-cell sequencing to identify their cellular mechanisms in the tumor microenvironment.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

Distinct cell states define the developmental trajectories of mucinous appendiceal neoplasms towards pseudomyxoma metastases

C. Ayala, A. Sathe, X. Bai, S. M. Grimes, J. Shen, G. A. Poultsides, B. Lee, H. P. Ji

This study uses single-cell RNA-sequencing to identify distinct cell states in appendiceal mucinous neoplasms and their progression to pseudomyxoma peritonei, revealing developmental trajectories and signaling pathway changes.

bioRxiv · May 26, 2022 · PreprintCancer Biology

Colorectal cancer metastases in the liver establish immunosuppressive spatial networking between tumor associated SPP1+ macrophages and fibroblasts

A. Sathe, K. Mason, S. M. Grimes, Z. Zhou, B. T. Lau, X. Bai, A. Su, X. Tan, H. Lee, C. Suarez, Q. Nguyen, G. Poultsides, N. Zhang, H. P. Ji

This paper identifies SPP1+ macrophages and fibroblasts in liver metastatic CRC TME that form immunosuppressive networks, promoting tumor growth and poor prognosis.

bioRxiv · Sep 1, 2020Cancer Biology