Author

R. K. Shrestha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Plant Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 3 Assay:ATAC-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

A. J. Hoy· 2 shared B. P. M. Ngou· 2 shared D. J. Lynn· 2 shared D. MacLean· 2 shared J. D. Jones· 2 shared L. A. Selth· 2 shared L. M. Butler· 2 shared M. M. Centenera· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

A. J. Hoy

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Author profile →

5 papers

Recent·Most cited

Mutational analysis of a conserved positive charge in the c-ring of E. coli ATP synthase

R. K. Shrestha, M. W. Founds, S. J. Shepard, M. M. Rothrock, A. E. Defnet, R. Steed

The paper investigates the role of conserved positive charges in E. coli ATP synthase by analyzing mutations affecting proton translocation and ATP synthesis.

bioRxiv · Jul 28, 2022Biochemistry

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

J. L. Gillis, J. A. Hinneh, N. K. Ryan, S. Irani, M. Moldovan, R. K. Shrestha, L.-E. Quek, A. J. Hoy, J. Holst, M. M. Centenera, I. G. Mills, D. J. Lynn, L. A. Selth, L. M. Butler

This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.

bioRxiv · Sep 2, 2020Cancer Biology

Chromatin accessibility landscapes activated by cell surface and intracellular immune receptors

P. Ding, T. Sakai, R. K. Shrestha, N. M. Perez, W. Guo, B. P. M. Ngou, S. He, C. Liu, X. Feng, R. Zhang, K. Vandepoele, D. MacLean, J. D. Jones

The paper uses RNA-seq and ATAC-seq to show that both SRMI and IRMI increase chromatin accessibility at defense genes, revealing overlapping transcriptional regulatory mechanisms.

bioRxiv · Jun 17, 2020Plant Biology

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Z. D. Nassar, C. Y. Mah, J. Dehairs, I. J. G. Burvenich, S. Irani, M. M. Centenera, R. K. Shrestha, M. Moldovan, A. S. Don, A. M. Scott, L. G. Horvath, D. J. Lynn, L. A. Selth, A. J. Hoy, J. V. Swinnen, L. M. Butler

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.

bioRxiv · Dec 6, 2019Cancer Biology

High-resolution Expression Profiling of Selected Gene Sets during Plant Immune Activation

P. Ding, B. P. M. Ngou, O. J. Furzer, T. Sakai, R. K. Shrestha, D. MacLean, J. D. Jones

The paper develops a method to assess differential gene expression of selected genes during plant immune activation using sequence capture and RNA-seq.

bioRxiv · Sep 23, 2019Plant Biology