Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis
Lars Borgards, Hannah Voß, Stephanie Tautges, Bente Siebels, Christoph Krisp, Devon Siemes, Philippa Spangenberg, Jenny Bottek, Sarah Scharfenberg, J. J. F. Schmitz, Lisa Schwarz, Christian Rehme, Boris Alexander Hadaschik, Jan Hinrich Braesen, Alexander Roesch, , Daniel Robert Engel
This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.
bioRxiv · Apr 13, 2026 · PreprintImmunology