Author

Philippa Spangenberg

Essen University HospitalORCID 0000-0002-5593-5546Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:clustering· 1 Research Focus:dimensionality reduction· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Daniel Robert EngeliD· 5 shared Devon SiemesiD· 5 shared Olga ShevchukiD· 4 shared Bente SiebelsiD· 3 shared Hannah VoßiD· 3 shared Hartmut SchlüteriD· 3 shared Jenny BottekiD· 3 shared Matthias GunzeriD· 3 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

Daniel Robert EngelORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Integrated kidney and urine proteomics define encrypted antimicrobial peptides as effectors of host defence in human pyelonephritis

Lars Borgards, Hannah Voß, Stephanie Tautges, Bente Siebels, Ekaterina Pylaeva, Philippa Spangenberg, Devon Siemes, Christoph Krisp, Jessica Schmitz, Lisa Cinkul, Damilola Emmanuel Akinyemi, Annika Hilger, Paulina Szymczak, Anne-Christine Aust, Jan Hinrich Braesen, , Olga Shevchuk

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

bioRxiv · Apr 14, 2026 · PreprintImmunology

Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis

Lars Borgards, Hannah Voß, Stephanie Tautges, Bente Siebels, Christoph Krisp, Devon Siemes, Philippa Spangenberg, Jenny Bottek, Sarah Scharfenberg, J. J. F. Schmitz, Lisa Schwarz, Christian Rehme, Boris Alexander Hadaschik, Jan Hinrich Braesen, Alexander Roesch, , Daniel Robert Engel

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

bioRxiv · Apr 13, 2026 · PreprintImmunology

TSP1/TGF-β1 drives arachidonic acid metabolism to orchestrate neutrophil swarming

Lars Widera, Philippa Spangenberg, Devon Siemes, Sebastian Bessler, Jenny Bottek, Hannah Voß, Angelo Novak, Darleen Hueser, Mathis Richter, Alexander Potthoff, Bente Siebels, Manuela Moritz, Antonia Gocke, Stephanie Thiebes, Stephanie Tautges, , Daniel Robert Engel

The paper identifies TSP1/TGF-β1 as a key driver of neutrophil swarming through arachidonic acid metabolism in a urinary tract infection model.

bioRxiv · Nov 25, 2025 · PreprintImmunology

msiFlow: Automated Workflows for Reproducible and Scalable Multimodal Mass Spectrometry Imaging and Immunofluorescence Microscopy Data Processing and Analysis

Philippa Spangenberg, Sebastian Bessler, Lars Widera, Jenny Bottek, Mathis Richter, Stephanie Thiebes, Devon Siemes, Sascha D. Krauß, Lukasz G. Migas, Siva Swapna Kasarla, Prasad B. Phapale, Jens Kleesiek, Dagmar Führer, Lars Christian Moeller, Heike Heuer, , Daniel Robert Engel

msiFlow automates and streamlines multimodal mass spectrometry imaging and immunofluorescence data analysis to enhance reproducibility and scalability in biological research.

bioRxiv · Aug 24, 2024 · PreprintBioinformatics

Rapid and fully automated blood vasculature analysis in 3D light-sheet image volumes of different organs

Philippa Spangenberg, Nina Hagemann, Anthony Squire, Nils Förster, Sascha D. Krauß, Yachao Qi, Ayan Mohamud Yusuf, Jing Wang, Anika Grüneboom, Lennart Kowitz, Sebastian Korste, Matthias Totzeck, Zülal Cibir, Ali Ata Tuz, Vikramjeet Singh, , Axel Mosig A

VesselExpress automates 3D blood vasculature analysis in LSFM data, enabling rapid and unbiased quantification of vascular parameters across multiple organs.

Cell Reports Methods · Mar 1, 2023Peer-reviewedBioinformatics