Florian Wagenlehner

Complement receptor-mediated uptake into renal mononuclear phagocytes promotes intracellular UPEC persistence and limits β-lactam efficacy in pyelonephritis

This study identifies renal mononuclear phagocytes as an intracellular reservoir for UPEC in pyelonephritis, showing that complement receptor-mediated entry promotes bacterial persistence and limits β-lactam efficacy.

Integrated kidney and urine proteomics define encrypted antimicrobial peptides as effectors of host defence in human pyelonephritis

The paper integrates kidney and urine proteomics with peptidomics and machine learning to identify encrypted antimicrobial peptides as functional effectors in human pyelonephritis.

Lactate-dependent metabolic rewiring is associated with CD163+ macrophage polarization in human pyelonephritis

This study identifies lactate as a metabolic driver of CD163+ macrophage polarization in human pyelonephritis, linking lactate metabolism to immune dysfunction.

Rapid clinical metagenomics enables early tailored therapy in complicated urinary tract infections and strengthens antimicrobial stewardship

This paper evaluates URINN, a metagenomic workflow for rapid UTI diagnosis, showing high accuracy in pathogen detection and antibiotic resistance prediction.