Author

J. J. Lucas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

S. Pico· 2 shared A. Balaceanu· 1 shared A. Bartomeu· 1 shared A. Lopez-Marquez· 1 shared A. Martinez-Pizarro· 1 shared B. Duran-Arque· 1 shared B. Perez· 1 shared C. De Pace· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPathology

S. Pico

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PAH DEFICIENT PATHOLOGY IN HUMANIZED c.1066-11G>A PHENYLKETONURIA MICE

A. Martinez-Pizarro, S. Pico, A. Lopez-Marquez, C. Rodriguez-Lopez, E. Montalvo, M. Alvarez, M. Castro, S. Ramon-Maiques, B. Perez, J. J. Lucas, E. M. Richard, L. R. Desviat

This paper generates a partially humanized mouse model of PKU with the c.1066-11G>A PAH variant, showing splicing defects, metabolic imbalances, and neurological phenotypes.

bioRxiv · Nov 3, 2023 · PreprintPathology

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

C. Garcia-Cabau, A. Bartomeu, G. Tesei, K. C. Cheung, J. Pose-Utrilla, S. Pico, A. Balaceanu, B. Duran-Arque, M. Fernandez-Alfara, J. Martin, C. De Pace, L. Ruiz-Perez, J. Garcia, G. Battaglia, J. J. Lucas, , X. Salvatella

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

bioRxiv · Mar 19, 2023Biophysics