G. Battaglia

Imaging Abeta aggregation by liquid-phase transmission electron microscopy

This study uses liquid-phase transmission electron microscopy to visualize Aβ aggregation dynamics and intermediate oligomers in solution.

SimpliPyTEM: An open-source Python library and app to simplify Transmission Electron Microscopy and in situ-TEM image analysis.

SimpliPyTEM simplifies TEM image analysis by converting low-contrast images into high-quality outputs and processing in situ TEM videos for scientific use.

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

The Role of Glycocalyx Steric Effects on Viral Endocytosis

This paper develops a thermodynamic model of viral entry that highlights the role of glycocalyx structure and co-receptors in determining viral cell entry.

A Multiscale study of phosphorylcholine driven cellular phenotypic targeting

This study demonstrates how promiscuous ligands can be used to create multiplexed-multivalent carriers for phenotypic targeting, showing that PMPC-PDPA polymersomes can target monocytes in vivo.

Targeting activated macrophages intracellular milieu to augment anti-inflammatory drug potency

This study demonstrates that pH-responsive polymersomes enhance methotrexate delivery to activated macrophages, improving arthritis treatment while reducing off-target effects.

The role of host cell glycans on virus infectivity: The SARS-CoV-2 case

This study investigates how host cell glycans, specifically Heparan Sulfate chains and ACE2/TMPRSS2 receptors, influence SARS-CoV-2 infectivity through attractive and repulsive interactions.

4D imaging of soft matter in liquid water

This paper introduces brownian tomography to image soft matter in liquid water, achieving sub-nanometer resolution and capturing conformational changes and hydration dynamics.

Combinatorial Intracellular Delivery Screening (CIDS) of Anticancer Drugs

This study introduces a method using PMPC-PDPA polymersomes to enhance intracellular delivery of poorly water-soluble anticancer drugs and identifies synergistic drug combinations.

Microtubule Probe for Correlative Super-Resolution Fluorescence and Electron Microscopy

The paper introduces a microtubule probe that enables correlative super-resolution fluorescence and electron microscopy to study microtubule ultrastructure.

Chemotactic synthetic vesicles: design and applications in blood brain barrier crossing

This paper designs synthetic vesicles that exhibit chemotaxis by converting glucose, showing improved brain penetration compared to non-chemotactic systems.