Author

S. Pico

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Ocampo· 2 shared F. von Meyenn· 2 shared J. J. Lucas· 2 shared A. Alonso-Calleja· 1 shared A. Balaceanu· 1 shared A. Bartomeu· 1 shared A. Haghani· 1 shared A. Lopez-Marquez· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersPhysiology

A. Ocampo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of H3K9 trimethylation leads to premature aging

C. Mrabti, N. Yang, G. Desdin-Mico, A. Alonso-Calleja, A. Vilchez-Acosta, S. Pico, A. Parras, Y. Piao, L. Schoenfeldt, S. Luo, A. Haghani, R. Brooke, M. d. C. Maza, C. Branchina, C. Yacoub Maroun, , A. Ocampo

This study shows that loss of H3K9me3 in adult mice leads to premature aging, characterized by reduced lifespan, frailty, and accelerated epigenetic aging.

bioRxiv · Jul 24, 2024 · PreprintPhysiology

In vivo reprogramming of Caenorhabditis elegans leads to heterogeneous effects on lifespan

N. H. Kamaludeen Mariyath, Y. Mauge, S. El Mouridi, S. Pico, A. Vilchez Acosta, J. A. de Sousa, M. Pierron, V. Praz, F. von Meyenn, C. Frokjaer-Jensen, A. Ocampo

This study induces in vivo reprogramming in C. elegans and finds it leads to heterogeneous effects on lifespan depending on developmental stage.

bioRxiv · May 3, 2024 · PreprintCell Biology

PAH DEFICIENT PATHOLOGY IN HUMANIZED c.1066-11G>A PHENYLKETONURIA MICE

A. Martinez-Pizarro, S. Pico, A. Lopez-Marquez, C. Rodriguez-Lopez, E. Montalvo, M. Alvarez, M. Castro, S. Ramon-Maiques, B. Perez, J. J. Lucas, E. M. Richard, L. R. Desviat

This paper generates a partially humanized mouse model of PKU with the c.1066-11G>A PAH variant, showing splicing defects, metabolic imbalances, and neurological phenotypes.

bioRxiv · Nov 3, 2023 · PreprintPathology

Kinetic stabilization of translation-repression condensates by a neuron-specific microexon

C. Garcia-Cabau, A. Bartomeu, G. Tesei, K. C. Cheung, J. Pose-Utrilla, S. Pico, A. Balaceanu, B. Duran-Arque, M. Fernandez-Alfara, J. Martin, C. De Pace, L. Ruiz-Perez, J. Garcia, G. Battaglia, J. J. Lucas, , X. Salvatella

The paper shows that a neuron-specific microexon in CPEB4 stabilizes translation-repression condensates by competing with aggregation, enabling reversible regulation of gene expression in neurons.

bioRxiv · Mar 19, 2023Biophysics