J. Jean Chen

Intranasal photobiomodulation as an energy-efficient, largely parameter-insensitive alternative to transcranial photobiomodulation

This study compares intranasal and transcranial photobiomodulation, finding that intranasal delivers similar EEG effects with less energy and is insensitive to parameters and individual differences.

Dose dependence and neurovascular mechanisms of the fMRI response to pulsed photobiomodulation in humans

This study investigates the dose-dependent fMRI response to transcranial photobiomodulation in humans, showing non-local effects and parameter-dependent responses.

Orientation Dependence of R2' in White Matter: Digital Characterization, Modelling and Implications for Studying Brain Physiology

This study characterizes the orientation dependence of R2' in white matter, develops a new Myelin-Blood model, and shows it improves R2' fitting compared to existing models.

Reduced Blood Flow in Deep White Matter During Hypercapnia Revealed by Multi-Delay pCASL in Healthy Young Adults

This study uses multi-delay pCASL to show that deep white matter has little to no increase in blood flow during hypercapnia, unlike other brain regions.

Characterization and Validation of Compressed Sensing for Time-of-Flight MRI Angiography of the Human Brain at 3T and 7T

This study evaluates compressed sensing in TOF-MRA at 3T and 7T, finding significant differences in CNR and vessel diameter measurements across CS factors.

Inter-individual differences in cerebrovascular reactivity are synchronized within functional networks and tissue layers: evidence from healthy older adults and patients with hypertension

This study shows that cerebrovascular reactivity (CVR) amplitude and lag co-vary within resting-state networks and tissue layers in healthy older adults and those with hypertension.

Intranasal photobiomodulation: an energy efficient paradigm for cortical and subcortical stimulation

This study shows intranasal photobiomodulation (iPBM) is more efficient than forehead PBM in eliciting BOLD fMRI responses and reveals sex differences in its effects.

Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system

This study investigates how baseline CO2 levels modulate neurofluid dynamics in awake humans, showing that autonomic nervous system regulation affects flow through frequency changes rather than amplitude.

Evaluating BOLD functional MRI biophysical simulation approaches: impact of vascular geometry, magnetic field calculations, and water diffusion models

This paper compares eight BOLD fMRI simulation approaches, finding that most are accurate but some are biased, with intravascular signal differences affecting results.

The link between steady-state EEG and rs-fMRI metrics in healthy young adults: the effect of macrovascular correction

This study shows macrovascular correction improves the relationship between EEG and rs-fMRI metrics, and sex modulates EEG-fMRI associations, with EEG complexity linked to resting-state functional activity.

Association between white-matter lesion volume and heart-rate variability: A comparison of T1w, T1w+T2w and T1w+FLAIR-based segmentations using FreeSurfer SAMSEG

This paper examines the association between white-matter lesion volume and heart-rate variability using different MRI segmentation methods in a healthy adult cohort.

Real-time spatial evolution of the fMRI response to photobiomodulation in the healthy human brain

This study uses BOLD-fMRI to map real-time spatial and temporal changes in brain activity induced by transcranial photobiomodulation in healthy humans.

Linking Electrophysiological Metrics to Oxidative Metabolism: Implications for EEG-fMRI Association

This study links electrophysiological metrics to oxidative metabolism and shows sex differences in their associations with rs-fMRI metrics.

Variations in perfusion detectable in advance of microstructure in white matter aging

This study examines the relationship between perfusion and white matter microstructure in aging, finding that arterial transit time declines before microstructural changes and varies by tract and sex.

Testing retrogenesis and physiological explanations for tract-wise white matter aging: links to developmental order, fibre calibre, and vascularization

The paper investigates whether white matter aging follows developmental order (retrogenesis) or physiological factors like fibre size and perfusion, finding mixed support for both theories.

Pulsed transcranial photobiomodulation evokes sustained, parameter-dependent changes in EEG oscillations that run opposite to frequency entrainment

This study investigates how pulsed transcranial photobiomodulation (tPBM) parameters affect EEG oscillations, finding parameter-dependent changes that contradict entrainment predictions and highlighting sex as a key biological modulator.

Modulating cerebrospinal fluid dynamics using pulsed photobiomodulation: feasibility, parameter and skin-colour dependence

This study shows that pulsed photobiomodulation can increase cerebrospinal fluid flow in healthy adults, with effects influenced by skin color and irradiance-wavelength interactions.

Sex-specific effects of intensity and dose of physical activity on BOLD-fMRI cerebrovascular reactivity and cerebral pulsatility

This study examines how physical activity intensity and dose affect cerebrovascular reactivity and pulsatility differently in men and women, finding sex-specific patterns influenced by menopause.

The Link to Oxidative Metabolism Varies across rs-fMRI Metrics: A Whole-Brain Assessment Using Macrovascular Correction

This study links rs-fMRI metrics to oxidative metabolism (CMRO2) and shows macrovascular correction improves model fit and interpretability.

Comparing data-driven physiological denoising approaches for resting-state fMRI: Implications for the study of aging

This study compares physiological denoising methods for resting-state fMRI, finding that ICA-AROMA and GSR remove more noise but also age-related functional connectivity differences, while aCompCor and tCompCor better preserve fcMRI information.

In search of a unifying theory of white matter aging: improving the understanding of tract-wise degeneration using multi-parametric signatures of morphometry and microstructure

This study examines age-related changes in white matter tracts using morphometry and microstructural metrics to identify sex-specific degeneration patterns and propose a unified model of WM aging.

Widespread Autonomic Physiological Coupling Across the Brain-Body Axis

This study identifies widespread brain-body co-fluctuations across multiple physiological systems and shows they are linked to autonomic nervous system activity.

Is adiposity associated with white matter microstructural health and intelligence differently in men and women?

This study examines how adiposity relates to white matter microstructural health and intelligence, finding sex differences in these associations.

Generating dynamic carbon-dioxide from the respiratory-volume time series: A feasibility study using neural networks

This study uses neural networks to reconstruct CO2 and PETCO2 data from respiration waveforms in resting-state fMRI, achieving high correlation with ground truth data.

White matter microstructural integrity across the adult lifespan: Combined perspective of diffusion tensor and kurtosis imaging

This study compares diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) in UK Biobank data to assess how non-Gaussian diffusion metrics improve understanding of white matter aging.

Performance of temporal and spatial ICA in identifying and removing low-frequency physiological and motion effects in resting-state fMRI

This study compares spatial and temporal ICA for denoising resting-state fMRI, finding sICA better for motion and tICA for physiological noise, recommending a hybrid approach.

Controlling for the effect of arterial-CO2 fluctuations in resting-state fMRI: Comparing end-tidal CO2 clamping and retroactive CO2 correction

This study compares PETCO2 clamping and retroactive correction in resting-state fMRI to assess their impact on functional connectivity and signal stability.