K. Fang

Amyloid-β can activate JNK signalling via WNT-5A/ROR2 to reduce synapse formation in Alzheimer's disease.

This study shows that Amyloid-β activates JNK signaling through WNT-5A/ROR2, reducing synapse formation in Alzheimer's disease.

High Refractive Index Imaging Buffer for Dual Color 3D SMLM Imaging of Thick Samples

This paper develops a high refractive index imaging buffer to improve 3D SMLM imaging depth in thick samples by reducing RI mismatch and enhancing image quality.

Aberration correction for deformable mirror based remote focusing enables high-accuracy whole-cell super-resolution imaging

This paper develops a deformable mirror-based remote focusing system to enable high-accuracy whole-cell super-resolution imaging with uniform resolution across thick samples.

Hi-C profiling in tissues reveals 3D chromatin-regulated breast tumor heterogeneity and tumor-specific looping-mediated biological pathways

The paper uses Hi-C profiling in breast tissues to reveal 3D chromatin-regulated tumor heterogeneity and identifies CA2 as a driver of tamoxifen resistance through enhancer-promoter looping.

Aftiphilin regulation of myosin light chain kinase activity promotes actin dynamics and intestinal epithelial barrier function

This study shows that AFTPH regulates intestinal epithelial barrier function by modulating MLCK activity and actin dynamics in colonic epithelial cells.

Virulence evolution of multiple infections with vertically and horizontally transmitted fungal species in a natural plant system

This study examines virulence evolution in multiple infections of fungal pathogens with different transmission modes in a natural plant system, finding that vertical transmission correlates with decreased virulence while horizontal transmission correlates with increased virulence.

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum.

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

Nuclear export of chimeric mRNAs depends on an lncRNA-triggered autoregulatory loop

This study shows that MALAT1 regulates chimeric mRNA export via an m6A-dependent mechanism, influencing myeloid progenitor cell differentiation in hematopoiesis.