K. S. Tan

Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

This study evaluates a SARS-CoV-2 vaccine candidate that targets dendritic cells, showing durable systemic and mucosal immune responses against multiple variants.

Chloroquine induces eryptosis in P. falciparum-infected red blood cells and the release of extracellular vesicles with a unique protein profile

This study shows chloroquine induces eryptosis in P. falciparum-infected red blood cells, releasing EVs with unique proteomic profiles that may activate immune pathways.

Dual Recognition of Multiple Signals in Bacterial Outer Membrane Proteins Enhance Assembly and Maintain Membrane Integrity

The paper identifies an additional signal in bacterial outer membrane proteins that enhances assembly efficiency and maintains membrane integrity through interaction with BamD.

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

This paper enhances kidney organoid maturation to produce functional proximal tubules, enabling better toxicity screening and infectious disease modeling.

Direct cleavage of human NLRP1 by enteroviral 3C protease triggers inflammasome activation in airway epithelium

The paper identifies enteroviral 3C proteases as the first cognate PAMP ligand for human NLRP1, showing they trigger inflammasome activation and airway inflammation.

Calcitriol, the active form of vitamin D, is a promising candidate for COVID-19 prophylaxis

This study identifies calcitriol, the active form of vitamin D, as a potent inhibitor of SARS-CoV-2, suggesting its potential as a prophylactic agent against COVID-19.

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum.

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

Bioprinted pluripotent stem cell-derived kidney organoids provide opportunities for high content screening.

The paper demonstrates the use of bioprinted kidney organoids for high content drug screening, showing reproducibility and response to doxorubicin toxicity.