Z. Bozdech

Repeated Plasmodium vivax blood stage infection provides sterile protection against homologous challenge in non-human primates

This study shows that repeated P. vivax infections in Aotus monkeys induce sterile immunity against homologous strain challenges but only partial protection against heterologous strains.

The artemisinin-induced dormant stages of Plasmodium falciparum exhibit hallmarks of cellular senescence and drug resilience.

This study identifies artemisinin-induced dormant stages of Plasmodium falciparum as exhibiting senescence-like features and drug resistance.

Quinazoline-quinoline bisubstrate inhibitors target eukaryotic translation initiation factor 3 in Plasmodium falciparum

This study identifies PfEIF3i as a target of quinoline-quinazoline inhibitors in Plasmodium falciparum, showing its essential role in parasite development and potential as an antimalarial drug target.

Genomic, transcriptomic, and metabolomic analysis of Traditional Chinese Medicine plant Oldenlandia corymbosa reveals the biosynthesis and mode of action of anti-cancer metabolites

This study identifies ursolic acid as the main anti-cancer compound in Oldenlandia corymbosa and reveals its mode of action through genomic, transcriptomic, and metabolomic analysis.

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

This study shows that human PRDX6 is essential for malaria parasite survival by repairing lipid peroxidation damage and that inhibiting it can kill parasites, including artemisinin-resistant strains.

Identification of an inhibitory pocket in falcilysin provides a new avenue for malaria drug development

This study identifies falcilysin as a target of anti-malaria drugs and reveals a shared inhibitory pocket that could guide new drug development.

The PfAP2-HS transcription factor protects malaria parasites from febrile temperatures

This study identifies PfAP2-HS as a transcription factor that enables malaria parasites to survive febrile temperatures by activating chaperone genes.

Reverse transcription quantitative PCR to detect low density malaria infections

This study evaluates a qRT-PCR method for detecting low density malaria infections with reduced sample volume compared to uPCR, showing improved sensitivity and specificity in a Myanmar cohort.

Reticulocyte Infection Leads to Altered Behaviour, Drug Sensitivity and Host Cell Remodelling by Plasmodium falciparum.

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

Whole Cell Phenotypic Screening Of MMV Pathogen Box identifies Specific Inhibitors of Plasmodium falciparum merozoite maturation and egress.

The paper screens the MMV Pathogen Box to identify inhibitors of Plasmodium falciparum merozoite maturation and egress, finding 12 potent and selective blockers.