Author

J. K. Varga

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

O. Schueler-Furman· 3 shared M. Kumar· 2 shared M. N. Isupov· 2 shared R. Wiener· 2 shared A. A. Jeyaprakash· 1 shared A. Kettenbach· 1 shared A. Rouvinski· 1 shared B. Lopez-Mendez· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

O. Schueler-Furman

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Binding of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition

J. Fahoum, M. Billan, J. K. Varga, D. Padawer, M. Elgrably-Weiss, P. Basu, M. Stolovich-Rain, L. Baraz, S. Kumari, E. Oiknine-Dijan, M. Kumar, E. Cohen-Kfir, O. Zelig, G. Mayer, M. N. Isupov, , A. Rouvinski

This study shows that SARS-CoV-2 nucleocapsid protein binds to uninfected cells, triggering antibody-mediated complement activation in COVID-19 patients.

bioRxiv · Mar 17, 2024 · PreprintImmunology

Substrate recognition principles for the PP2A-B55 protein phosphatase

T. Kruse, D. Garvanska, J. K. Varga, W. Garland, B. McEwan, J. Hein, M. B. Weisser, I. B. Puy, C. Chan, P. S. Parrila, B. Lopez-Mendez, A. A. Jeyaprakash, O. Schueler-Furman, T. H. Jensen, A. Kettenbach, J. Nilsson

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

bioRxiv · Feb 10, 2024Cell Biology

Structural study of UFL1-UFC1 interaction uncovers the importance of UFL1 N-terminal helix for ufmylation

S. Banerjee, J. K. Varga, M. Kumar, G. Zoltsman, M. N. Isupov, R. Rosenzweig, O. Schueler-Furman, R. Wiener

This study reveals the role of UFL1's N-terminal helix in binding UFC1 and ufmylation, uncovering a helix-mediated regulatory mechanism in the E1-E2-E3 cascade.

bioRxiv · Sep 15, 2022 · PreprintBiochemistry