B. Lopez-Mendez

Substrate recognition principles for the PP2A-B55 protein phosphatase

The paper identifies conserved mechanisms by which PP2A-B55 substrates bind B55 through α-helices and develops a competitive inhibitor to study its function.

STREAMLINED PROTEOME-WIDE IDENTIFICATION OF DRUG TARGETS INDICATES ORGAN-SPECIFIC ENGAGEMENT

The paper develops a proteomics method to identify drug targets across the proteome, revealing organ-specific interactions and global drug effects.

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection

This study identifies a novel interaction between SARS-CoV-2 NSP3 and FMRPs, showing that this interaction is critical for viral replication and disease progression.

Global substrate identification and high throughput in vitro dephosphorylation reactions uncover PP1 and PP2A-B55 specificity principles

The paper develops an in vitro assay to determine phosphatase specificity and applies it to study mitotic exit, revealing substrate preferences and biological relevance.

Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

The paper presents the cryo-EM structure of the TnsB transposase-DNA complex from a type V-K CRISPR-associated transposon, revealing its architecture and catalytic mechanism.

Separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis

This study shows that separating kinase and phosphatase activities in the Bub complex is essential for proper mitosis, as merging these functions leads to mitotic defects.

Cellular toxicity of iHAP1 and DT-061 does not occur through PP2A-B56 targeting

This study challenges previous claims that iHAP1 and DT-061 target PP2A-B56 complexes, showing instead that they exert toxicity through microtubule disruption and ER/Golgi disruption, respectively.