Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity
A. R. DiNardo, K. Rajapakshe, T. Nishiguchi, G. Mtetwa, Q. Dlamini, J. Kahari, S. Mahapatra, A. Kay, G. Maphalala, E. Mace, S. L. Grimm, G. Makedonas, J. D. Cirillo, M. G. Netea, R. van Crevel, , A. M. Mandalakas
This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.
bioRxiv · Oct 16, 2019 · PreprintImmunology