S. Mahapatra

p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer

This study shows that degrading p300/CBP in prostate cancer suppresses tumor growth more effectively than inhibiting their activity, highlighting their role in maintaining the active AR enhanceosome.

Development of an orally bioavailable mSWI/SNF ATPase degrader and acquired mechanisms of resistance in prostate cancer

This paper develops an orally bioavailable PROTAC degrader of mSWI/SNF ATPases for prostate cancer and identifies resistance mechanisms through long-term treatment.

Unleashing precision and freedom of optical manipulation: Software-aided real-time precision opto-control of intracellular molecular activities and cell functions

This paper introduces a software-assisted real-time optical manipulation platform for precise control of intracellular processes and cell functions.

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

Quantification of cellular phototoxicity of organelle stains by the dynamics of microtubule polymerization

The paper quantifies early-stage phototoxicity of organelle stains by analyzing microtubule polymerization dynamics in live cells under different conditions.

Spatiotemporal precise optical manipulation of intracellular molecular activities

This paper develops a closed-loop optoelectronic system to precisely control molecular activities in live cells, demonstrating spatiotemporal manipulation of reactive oxygen species and tubulin polymerization.

ATP modulates self-perpetuating conformational conversion generating structurally distinct yeast prion amyloids that limit autocatalytic amplification

This study shows ATP modulates yeast prion amyloid formation and limits autocatalytic amplification by altering aggregate structure and fragmentation.

Repressing ABCB7 Potentiates Cisplatin Response in Pediatric Group 3 Medulloblastoma by Triggering Ferroptosis

This study shows that repressing ABCB7 in group 3 medulloblastoma triggers ferroptosis, enhancing cisplatin response and survival.

MiR-212-3p functions as a tumor suppressor gene in group 3 medulloblastoma via targeting Nuclear Factor I/B (NFIB)

This study identifies miR-212-3p as a tumor suppressor in group 3 medulloblastoma by targeting NFIB, reducing cancer cell proliferation and metastasis.

Sub-stoichiometric Hsp104 regulates the genesis and persistence of self-replicable amyloid seeds of a yeast prion protein

This study shows that low levels of Hsp104 promote the formation and persistence of amyloid seeds in yeast prion proteins.

Toward Minimally Invasive Therapeutic Ultrasound: Ultrasound-guided Ablation in Neuro-oncology

The paper develops and validates an ultrasound-guided focused ultrasound probe for minimally invasive neuro-oncology procedures, demonstrating its ability to ablate lesions in tissue-mimicking phantoms.

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.