Author

G. Maphalala

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

A. Kay· 2 shared A. M. Mandalakas· 2 shared A. R. DiNardo· 2 shared C. Coarfa· 2 shared G. Makedonas· 2 shared G. Mtetwa· 2 shared K. Rajapakshe· 2 shared T. Nishiguchi· 2 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

A. Kay

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

A. R. DiNardo, K. Rajapakshe, T. Nishiguchi, G. Mtetwa, Q. Dlamini, J. Kahari, S. Mahapatra, A. Kay, G. Maphalala, E. Mace, S. L. Grimm, G. Makedonas, J. D. Cirillo, M. G. Netea, R. van Crevel, , A. M. Mandalakas

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

bioRxiv · Oct 16, 2019 · PreprintImmunology

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

A. R. DiNardo, T. Nishiguchi, E. M. Mace, K. Rajapakshe, G. Mtetwa, A. Kay, G. Maphalala, W. E. Secor, R. A. Mejia, C. Coarfa, K. N. Bhalla, E. A. Graviss, J. S. Orange, G. Makedonas, A. M. Mandalakas

This study shows helminth infections cause long-term DNA methylation and immune changes that impair TB-specific immune responses.

bioRxiv · Jan 27, 2018Immunology

A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of the Mycobacterium tuberculosis complex by whole genome sequencing

S. I. W. Lipworth, R. Jajou, H. de Neeling, P. Bradley, W. van der Hoek, G. Maphalala, M. Bonnet, E. Sanchez-Padilla, R. Diel, S. Niemann, Z. Iqbal, G. Smith, T. Peto, D. Crook, T. M. Walker, D. van Soolingen

This paper introduces SNP-IT, a method using whole genome sequencing to identify subspecies and lineages of Mycobacterium tuberculosis complex, revealing high prevalence of M. orygis in UK clinical isolates.

bioRxiv · Jan 5, 2018Microbiology