Author

K. Rajapakshe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

C. Coarfa· 4 shared A. Kay· 2 shared A. M. Mandalakas· 2 shared A. Maitra· 2 shared A. R. DiNardo· 2 shared B. Ghosh· 2 shared G. Makedonas· 2 shared G. Maphalala· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

C. Coarfa

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

RET activation controlled by MAB21L4-CacyBP interaction drives squamous cell carcinoma

A. Srivastava, C. Tommasi, D. Sessions, A. Mah, T. Bencomo, J. M. Garcia, T. Jiang, M. Lee, J. Y. Shen, L. W. Seow, A. Nguyen, K. Rajapakshe, C. Coarfa, K. Y. Tsai, V. Lopez-Pajares, C. S. Lee

This study identifies RET activation driven by MAB21L4-CacyBP interaction as a driver of squamous cell carcinoma and shows RET inhibition as a potential therapeutic strategy.

bioRxiv · Jan 19, 2022 · PreprintCancer Biology

Oncogenic KRAS Requires Complete Loss of BAP1 Function for Development of Murine Intrahepatic Cholangiocarcinoma

R. K. Marcus, S. Ferri-Borgogno, A. Hosein, W. C. Foo, B. Ghosh, J. Zhao, K. Rajapakshe, J. Brugarolas, A. Maitra, S. Gupta

This study develops a mouse model showing that complete loss of BAP1 function is required for KRAS-driven intrahepatic cholangiocarcinoma.

bioRxiv · Oct 12, 2021Cell Biology

Loss of Rnf43 accelerates Kras-mediated neoplasia and remodels the tumor immune microenvironment in pancreatic adenocarcinoma

A. N. Hosein, G. Dangol, T. Okumura, J. Roszik, K. Rajapakshe, M. Siemann, B. Ghosh, M. E. Monberg, P. A. Guerrero, M. Zaid, A. A. Singhi, C. L. Haymaker, H. Clevers, S. M. Woermann, L. Abou-Elkacem, A. Maitra

This study shows that loss of Rnf43 accelerates Kras-driven pancreatic cancer and alters the tumor immune microenvironment by increasing lymphocytes and immune checkpoint expression.

bioRxiv · May 29, 2021Cancer Biology

STAT1 dissociates adipose tissue inflammation from insulin sensitivity in obesity

A. R. Cox, N. Chernis, D. A. Bader, P. Saha, P. M. Masschelin, J. B. Felix, Z. Lian, V. Putluri, K. Rajapakshe, K. H. Kim, D. T. Villareal, R. Armamento-Villareal, H. Wu, C. Coarfa, N. Putluri, S. M. Hartig

The paper investigates how STAT1 activity in adipocytes affects insulin sensitivity in obesity, finding that STAT1 deletion improves mitochondrial function but does not resolve insulin resistance.

bioRxiv · Apr 10, 2020Immunology

Persistent DNA Hyper-methylation Dampens Host Anti-Mycobacterial Immunity

A. R. DiNardo, K. Rajapakshe, T. Nishiguchi, G. Mtetwa, Q. Dlamini, J. Kahari, S. Mahapatra, A. Kay, G. Maphalala, E. Mace, S. L. Grimm, G. Makedonas, J. D. Cirillo, M. G. Netea, R. van Crevel, , A. M. Mandalakas

This study identifies DNA hyper-methylation in immune-related pathways of TB patients, leading to reduced immune responsiveness to mycobacterial antigens.

bioRxiv · Oct 16, 2019 · PreprintImmunology

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-specific Immune Changes

A. R. DiNardo, T. Nishiguchi, E. M. Mace, K. Rajapakshe, G. Mtetwa, A. Kay, G. Maphalala, W. E. Secor, R. A. Mejia, C. Coarfa, K. N. Bhalla, E. A. Graviss, J. S. Orange, G. Makedonas, A. M. Mandalakas

This study shows helminth infections cause long-term DNA methylation and immune changes that impair TB-specific immune responses.

bioRxiv · Jan 27, 2018Immunology