Author

J. Karlsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Bioengineering· 1 Cell Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:gene regulatory network inference· 3 Assay:imaging· 3 Approach:statistical model· 3 Approach:deep learning· 2 Research Focus:differential expression· 2

Frequent Co-Authors

A. Manas· 2 shared D. Bexell· 2 shared D. Gisselsson· 2 shared H. Jespersen· 2 shared J. A. Nilsson· 2 shared K. Hansson· 2 shared K. Radke· 2 shared L. M. Nilsson· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersEvolutionary Biology

A. Manas

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Author profile →

7 papers

Recent·Most cited

Inherent evolutionary unpredictability in cancer model system

S. Chattopadhyay, J. Karlsson, A. Manas, R. Kanzaki, E. Fredlund, A. J. Murphy, C. L. Morton, M. A. Woolard, N. Andersson, K. Hansson, K. Radke, A. M. Davidoff, S. Mohlin, K. Pietras, D. Bexell, D. Gisselsson

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

bioRxiv · Jun 1, 2022Evolutionary Biology

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

A. Manas, K. Aaltonen, N. Anderson, K. Hansson, A. Adamska, A. Seger, H. Yasui, H. van den Bos, K. Radke, J. Esfandyari, M. S. Bhave, J. Karlsson, D. C. J. Spierings, F. Foijer, D. Gisselsson, D. Bexell

The paper applies a clinically-relevant chemotherapy regimen to neuroblastoma PDX models to identify transcriptional patterns and mechanisms of chemoresistance.

bioRxiv · Apr 1, 2022Cancer Biology

Epigenetic therapy to enhance therapeutic effects of PD-1 inhibition in uveal melanoma

V. R. Sah, H. Jespersen, J. Karlsson, M. Lindberg, L. M. Nilsson, L. Ny, J. A. Nilsson

This study investigates enhancing PD-1 inhibitor efficacy in uveal melanoma through epigenetic modulation with HDAC or BET inhibitors, finding that HDAC inhibition synergizes with immunotherapy.

bioRxiv · Feb 4, 2021Cancer Biology

Convolutional neural networks for automated CMR image segmentation in rats with myocardial infarcts

A. Gondova, M. Zurek, J. Karlsson, L. Hultin, T. Noeske, E. Watson

This paper develops an AI tool using convolutional neural networks to automate LV segmentation in rat CMR images, achieving high accuracy and reducing manual effort.

bioRxiv · Dec 1, 2020 · PreprintBioengineering

Deep learning models for lipid-nanoparticle-based drug delivery

P. J. Harrison, H. Wieslander, A. Sabirsh, J. Karlsson, V. Malmsjö, A. Hellander, C. Wählby, O. Spjuth

The paper uses deep learning models to predict GFP expression in HepG2 cells exposed to lipid-nanoparticle-based mRNA therapeutics, showing improved performance with temporal dynamics modeling.

bioRxiv · Apr 6, 2020Cell Biology

Molecular profiling of driver events and tumor-infiltrating lymphocytes in metastatic uveal melanoma

J. Karlsson, L. M. Nilsson, E. M. Forsberg, S. Mitra, S. Alsen, G. Shelke, V. R. Sah, U. Stierner, C. All-Eriksson, B. Einarsdottir, H. Jespersen, L. Ny, P. Lindner, E. Larsson, R. Olofsson Bagge, J. A. Nilsson

This study profiles genomic and transcriptomic features of metastatic uveal melanoma, identifying BAP1 inactivation and immune checkpoint receptor expression in tumor-infiltrating lymphocytes.

bioRxiv · Aug 21, 2019Cancer Biology

A regulatory RNA is associated to invasive meningococcal disease in Europe

J. Karlsson, H. Eichner, S. Jacobsson, E. Loh

The study identifies a regulatory RNA polymorphism linked to increased virulence in invasive meningococcal disease in Europe.

bioRxiv · Mar 20, 2019 · PreprintMicrobiology