Author

D. Bexell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. Manas· 3 shared D. Gisselsson· 2 shared J. Esfandyari· 2 shared J. Karlsson· 2 shared K. Aaltonen· 2 shared K. Hansson· 2 shared K. Radke· 2 shared S. Mohlin· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersEvolutionary Biology

A. Manas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inherent evolutionary unpredictability in cancer model system

S. Chattopadhyay, J. Karlsson, A. Manas, R. Kanzaki, E. Fredlund, A. J. Murphy, C. L. Morton, M. A. Woolard, N. Andersson, K. Hansson, K. Radke, A. M. Davidoff, S. Mohlin, K. Pietras, D. Bexell, D. Gisselsson

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

bioRxiv · Jun 1, 2022Evolutionary Biology

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

A. Manas, K. Aaltonen, N. Anderson, K. Hansson, A. Adamska, A. Seger, H. Yasui, H. van den Bos, K. Radke, J. Esfandyari, M. S. Bhave, J. Karlsson, D. C. J. Spierings, F. Foijer, D. Gisselsson, D. Bexell

The paper applies a clinically-relevant chemotherapy regimen to neuroblastoma PDX models to identify transcriptional patterns and mechanisms of chemoresistance.

bioRxiv · Apr 1, 2022Cancer Biology

Engineering of human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia and solid tumor metastasis

A. Grigoryan, D. Zacharaki, A. Balhuizen, C. R. Come, A.-K. Frank, A. Garcia Garcia, K. Aaltonen, A. Manas, J. Esfandyari, N. Kalantari, P. Kjellman, S. Prithiviraj, E. Englund, C. D. Madsen, B. Porse, , P. E. Bourgine

This study develops standardized humanized mini-bones to model hematopoiesis, leukemia, and solid tumor metastasis by engrafting human blood and cancer samples.

bioRxiv · Sep 11, 2021Bioengineering

An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite

T. van Groningen, C. U. Niklasson, A. Chan, N. Akogul, E. M. Westerhout, K. von Stedingk, M. Hamdi, L. J. Valentijn, S. Mohlin, P. Stroeken, N. E. Hasselt, F. Haneveld, A. Lakeman, D. A. Zwijnenburg, P. van Sluis, , J. van Nes

The paper identifies an immature neuroblastoma subset that synthesizes retinoic acid and is resistant to it, potentially contributing to therapy-resistant relapses.

bioRxiv · May 18, 2021 · PreprintCancer Biology