Author

D. Gisselsson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

A. Manas· 2 shared D. Bexell· 2 shared J. Karlsson· 2 shared K. Hansson· 2 shared K. Radke· 2 shared A. Adamska· 1 shared A. J. Murphy· 1 shared A. Kock· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersEvolutionary Biology

A. Manas

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inherent evolutionary unpredictability in cancer model system

S. Chattopadhyay, J. Karlsson, A. Manas, R. Kanzaki, E. Fredlund, A. J. Murphy, C. L. Morton, M. A. Woolard, N. Andersson, K. Hansson, K. Radke, A. M. Davidoff, S. Mohlin, K. Pietras, D. Bexell, D. Gisselsson

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

bioRxiv · Jun 1, 2022Evolutionary Biology

Clinically-relevant treatment of PDX models reveals patterns of neuroblastoma chemoresistance

A. Manas, K. Aaltonen, N. Anderson, K. Hansson, A. Adamska, A. Seger, H. Yasui, H. van den Bos, K. Radke, J. Esfandyari, M. S. Bhave, J. Karlsson, D. C. J. Spierings, F. Foijer, D. Gisselsson, D. Bexell

The paper applies a clinically-relevant chemotherapy regimen to neuroblastoma PDX models to identify transcriptional patterns and mechanisms of chemoresistance.

bioRxiv · Apr 1, 2022Cancer Biology

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

J. Milosevic, S. Fransson, M. Gulyas, G. Gallo-Oller, T. K. Olsen, D. Treis, M. Wickstrom, L. H. Elfman, B. Sveinbjornsson, F. Hertwig, C. Bartenhagen, S. Reinsbach, M. Wilhelm, F. Abel, N. Javanmardi, , P. Kogner

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.

bioRxiv · Sep 4, 2020 · PreprintCancer Biology