Author

S. Mohlin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Research Focus:cell type annotation· 5 Approach:experimental assay· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Bexell· 2 shared E. Fredlund· 2 shared J. van Nes· 2 shared S. Andersson· 2 shared S. Karakaya· 2 shared S. Pahlman· 2 shared A. Bukkuri· 1 shared A. Chan· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersEvolutionary Biology

D. Bexell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cell Types or Cell States? An Investigation of Adrenergic and Mesenchymal Cell Phenotypes in Neuroblastoma

A. Bukkuri, S. Andersson, J. S. Brown, E. U. Hammarlund, S. Mohlin

The paper investigates whether adrenergic and mesenchymal phenotypes in neuroblastoma represent distinct cell types or dynamic cell states through theoretical modeling and hypothesis testing.

bioRxiv · Dec 20, 2023Cancer Biology

Compositional editing of extracellular matrices by CRISPR/Cas9 engineering of human mesenchymal stem cell lines

S. Prithiviraj, A. Garcia Garcia, K. Linderfalk, B. Yiguang, S. Ferveur, L. N. Falck, A. Subramaniam, S. Mohlin, D. H. Gil, S. J. Dupard, D. Zacharaki, D. B. Raina, P. E. Bourgine

This study uses CRISPR/Cas9 to edit human mesenchymal stem cells to produce engineered extracellular matrices with modified VEGF and RUNX2 expression, showing altered osteogenic properties.

bioRxiv · Jul 28, 2023Bioengineering

MOXD1 is a gate-keeper of organ homeostasis and functions as a tumor-suppressor in neuroblastoma

E. Fredlund, S. Andersson, E. Hilgert, G. Alvarez-Hernan, E. Monferrer, S. Karakaya, T. Gregor, S. Loontiens, J. W. Bek, E. Lecomte, E. Magnusson, E. Miltenyte, M. Cabirol, M. Kyknas, N. Engstrom, , S. Mohlin

The paper identifies MOXD1 as a tumor-suppressor gene in neuroblastoma by analyzing bulk and single-cell RNA sequencing data and validating its role in organ homeostasis across multiple species.

bioRxiv · Jan 17, 2023 · PreprintCancer Biology

Inherent evolutionary unpredictability in cancer model system

S. Chattopadhyay, J. Karlsson, A. Manas, R. Kanzaki, E. Fredlund, A. J. Murphy, C. L. Morton, M. A. Woolard, N. Andersson, K. Hansson, K. Radke, A. M. Davidoff, S. Mohlin, K. Pietras, D. Bexell, D. Gisselsson

This study shows that cancer evolution can be inherently unpredictable, using agent-based models and patient-derived xenograft data to demonstrate chaotic clonal dynamics.

bioRxiv · Jun 1, 2022Evolutionary Biology

Cytoplasmic HIF-2α correlates to proliferation and predicts worse outcome in sympathetic paraganglioma

S. Karakaya, L. Gunnesson, E. Elias, P. Martos Salvo, M. Robledo, O. Nilsson, B. Wängberg, F. Abel, S. Pahlman, A. Muth, S. Mohlin

The paper shows cytoplasmic HIF-2α correlates with proliferation and predicts poor outcomes in metastatic sympathetic paraganglioma.

bioRxiv · May 27, 2022 · PreprintCancer Biology

An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite

T. van Groningen, C. U. Niklasson, A. Chan, N. Akogul, E. M. Westerhout, K. von Stedingk, M. Hamdi, L. J. Valentijn, S. Mohlin, P. Stroeken, N. E. Hasselt, F. Haneveld, A. Lakeman, D. A. Zwijnenburg, P. van Sluis, , J. van Nes

The paper identifies an immature neuroblastoma subset that synthesizes retinoic acid and is resistant to it, potentially contributing to therapy-resistant relapses.

bioRxiv · May 18, 2021 · PreprintCancer Biology