Author

J. Campisi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 8 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 6 Organism:human· 6 Assay:proteomics· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3

Frequent Co-Authors

B. Schilling· 4 shared N. Basisty· 3 shared Q. Fu· 3 shared Q. Xu· 3 shared Y. Sun· 3 shared A. Kale· 2 shared C. Wang· 2 shared F. Neri· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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4 shared papersCell Biology

B. Schilling

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

A Fully-Automated Senescence Test (FAST) for the high-throughput quantification of senescence-associated markers

F. Neri, S. N. Takajjart, C. A. Lerner, P.-Y. Desprez, B. Schilling, J. Campisi, A. A. Gerencser

The paper introduces FAST, an automated method for high-throughput senescence quantification using image-based markers, showing it accurately measures senescence burden across cell types and reduces false positives.

bioRxiv · Dec 22, 2023Cell Biology

A Single Cell Time Course of Senescence Uncovers Discrete Cell Trajectories and Transcriptional Heterogeneity

S. Ciotlos, L. Wimer, J. Campisi, S. Melov

This study uses single-cell RNA sequencing to track senescent cell development over time, revealing distinct trajectories and transcriptional heterogeneity.

bioRxiv · Feb 17, 2023 · PreprintCell Biology

Senescent cells develop PDK4-dependent hypercatabolism and form an acidic microenvironment to drive cancer resistance

X. Dou, Q. Long, S. Liu, Y. Zou, D. Fu, X. Chen, Q. Xu, C. Wang, X. Ren, G. Zhang, Q. Fu, J. Campisi, Y. Zhao, Y. Sun

This study identifies PDK4-dependent hypercatabolism in senescent cells that creates an acidic microenvironment, promoting cancer resistance and age-related pathologies.

bioRxiv · Aug 29, 2022 · PreprintCell Biology

KDM4 Orchestrates Epigenomic Remodeling of Senescent Cells and Potentiates the Senescence-Associated Secretory Phenotype

B. Zhang, Q. Long, S. Wu, S. Song, Q. Xu, L. Han, M. Qian, X. Ren, J. Jiang, Q. Fu, J. Guo, X. Zhang, X. Chang, E. Lam, J. Campisi, , Y. Sun

This study shows KDM4 promotes epigenomic changes in senescent cells, enhances the SASP, and presents a therapeutic target for age-related diseases.

Nature Aging · May 13, 2021Peer-reviewedCell Biology

Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseases

Q. Xu, Q. Fu, Z. Li, H. Liu, Y. Wang, X. Lin, R. He, X. Zhang, J. Campisi, J. L. Kirkland, Y. Sun

This study identifies procyanidin C1 as a natural senolytic agent that selectively kills senescent cells and improves healthspan in aged animals.

bioRxiv · Apr 14, 2021 · PreprintCell Biology

Comprehensive Profiling of Plasma Exosomes Using Data Independent Acquisitions, New Tools for Aging Cohort Studies

S. K. Patel, R. Bruderer, N. Basisty, J. Bons, P.-Y. Desprez, F. Neri, L. Reiter, J. Campisi, B. Schilling

The paper develops a method to isolate and analyze plasma exosomes, identifying age-related protein and miRNA differences in an aging cohort.

bioRxiv · Feb 27, 2021 · PreprintCell Biology

ARYL HYDROCARBON RECEPTOR BLOCKS AGING-INDUCED SENESCENCE IN THE LIVER AND FIBROBLAST CELLS

A. Nacarino Palma, E. M. Rico Leo, J. Campisi, A. Ramanathan, J. M. Merino, P. M. Fernandez-Salguero

This study shows that the aryl hydrocarbon receptor (AhR) restricts aging-induced senescence in liver and fibroblast cells, reducing senescence markers and tumor burden.

bioRxiv · Feb 25, 2021Cancer Biology

Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung

N. Reyes de Mochel, K. N. Cheong, M. Cassandras, C. Wang, M. Krasilnikov, P. Matatia, A. Molofsky, J. Campisi, T. PENG

The paper identifies p16INK4a+ mesenchymal cells in the lung basement membrane as reparative sentinels that transition to a senescence-associated secretory phenotype to support epithelial repair.

bioRxiv · Jun 10, 2020 · PreprintCell Biology

A Proteomic Atlas of Senescence-Associated Secretomes for Aging Biomarker Development

N. Basisty, A. Kale, O. Jeon, C. Kuehnemann, T. Payne, C. Rao, A. Holtz, S. Shah, V. Sharma, L. Ferrucci, J. Campisi, B. Schilling

The paper develops a proteomic atlas of senescence-associated secretomes to identify aging biomarkers, finding that GDF15, STC1, and SERPINs correlate with age in human plasma.

bioRxiv · Aug 21, 2019Cell Biology

Aging-related inflammation driven by cellular senescence enhances NAD consumption via activation of CD38+ macrophages

A. J. Covarrubias, A. Kale, R. Perrone, J. A. Lopez-Dominguez, A. Oliveira Pisco, H. G. Kasler, M. S. Schmidt, C. D. Wiley, S. S. Iyer, N. Basisty, Q. Wu, R. Kwok, I. Heckenbach, K.-O. Shin, Y.-M. Lee, , E. Verdin

This study identifies CD38+ macrophages as a driver of NAD decline during aging through inflammation linked to cellular senescence in metabolic tissues.

bioRxiv · Jul 31, 2019Immunology