Author

J. L. Marin-Rubio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. Trost· 5 shared A. L. George· 2 shared M. E. Duenas· 2 shared A. Dannoura· 1 shared A. J. Simpson· 1 shared A. M. Frey· 1 shared A. Mendez-Alejandre· 1 shared B. B. A. Raymond· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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5 shared papersCancer Biology

M. Trost

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Author profile →

5 papers

Recent·Most cited

Mass spectrometry-based proteomic exploration of diverse murine macrophage cellular models

J. Gudgeon, J. L. Marin-Rubio, F. Sidgwick, M. Trost

The paper compares proteomic profiles of murine macrophage cell lines to primary and immortalised bone marrow-derived macrophages, identifying J774A.1 as the most similar to primary cells.

bioRxiv · Apr 9, 2024Immunology

Proteomic Analysis Reveals Trilaciclib-Induced Senescence

M. Hermosilla-Trespaderne, M. X. Hu-Yang, A. Dannoura, A. M. Frey, A. L. George, M. Trost, J. L. Marin-Rubio

This paper uses proteomics to show trilaciclib induces senescence in CML and NSCLC cells by stabilizing CDK4/6 and activating autophagy.

bioRxiv · Mar 12, 2024Cancer Biology

Bi-functional particles for real-time acidification and proteolysis multiplex assay in macrophages

A. Mendez-Alejandre, B. B. A. Raymond, M. Trost, J. L. Marin-Rubio

The paper develops a multiplexed assay to simultaneously monitor phagosome acidification and proteolysis in macrophages using silica beads conjugated to pHrodo and DQ BSA.

bioRxiv · Apr 3, 2023 · PreprintBiochemistry

A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling

A. L. George, F. R. Sidgwick, J. E. Watt, M. P. Martin, M. Trost, J. L. Marin-Rubio, M. E. Duenas

This study compares DIA-based label-free quantification methods with TMT-DDA for thermal proteome profiling, finding DIA approaches are comparable or better for detecting drug target engagement.

bioRxiv · Feb 15, 2023Biochemistry

A MALDI-TOF assay identifies nilotinib as an inhibitor of inflammation in acute myeloid leukaemia

J. L. Marin-Rubio, R. E. Heap, T. Heunis, M. E. Duenas, J. Inns, J. Scott, A. J. Simpson, J. M. Allan, H. Blair, O. Heidenreich, B. Saxty, M. Trost

This study identifies nilotinib as an anti-inflammatory drug using a MALDI-TOF assay in AML-derived monocytes, showing it inhibits the p38-MK2/3 signaling axis.

bioRxiv · Mar 29, 2021 · PreprintCancer Biology