A Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
A. L. George, F. R. Sidgwick, J. E. Watt, M. P. Martin, M. Trost, J. L. Marin-Rubio, M. E. Duenas
This study compares DIA-based label-free quantification methods with TMT-DDA for thermal proteome profiling, finding DIA approaches are comparable or better for detecting drug target engagement.
bioRxiv · Feb 15, 2023Biochemistry