Author

Andrew S. LaCroix

ORCID 0000-0003-0117-4785Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Assay:organoid / primary culture· 1 Research Focus:synaptic & neural circuits· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

Corey M. RountreeiD· 2 shared Nicholas Coungeris· 2 shared Victoria Alstat· 2 shared Christopher M. Butt· 1 shared Eva Schmidt· 1 shared J. Lowry Curley· 1 shared Megan Morris· 1 shared Michael John MooreiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

Corey M. RountreeORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintMay 23, 2026

Human CNS-3D organoids predict clinical seizure liability from calcium network activity

Andrew S. LaCroix, Nicholas Coungeris, Victoria Alstat…·Christopher M. Butt

The paper uses human CNS-3D organoids to predict clinical seizure liability based on calcium network activity, achieving high sensitivity and specificity.

DOI 10.64898/2026.05.20.726675

humanbulk RNA-seq

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BioengineeringbioRxivPreprintJul 3, 2025

Long-Term Potentiation and Closed-Loop Learning in Paired Brain Organoids for CNS Drug Discovery

Corey M. Rountree, Eva Schmidt, Nicholas Coungeris…·J. Lowry Curley

This study demonstrates LTP and closed-loop learning in paired brain organoids, showing BDNF's role in enhancing plasticity and linking game performance to cognitive function for CNS drug discovery.

5 citations

humanorganoid / primary culture

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