Author

J. M. Blake-Hedges

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:bacteria (other)· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. D. Keasling· 4 shared M. G. Thompson· 4 shared C. J. Petzold· 3 shared J. F. Barajas· 3 shared P. Cruz-Morales· 3 shared A. N. Pearson· 2 shared E. Baidoo· 2 shared J. W. Gin· 2 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersMicrobiology

J. D. Keasling

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Leveraging host metabolism for bisdemethoxycurcumin production in Pseudomonas putida

M. R. Incha, M. G. Thompson, J. M. Blake-Hedges, Y. Liu, A. N. Pearson, M. Schmidt, J. Gin, C. J. Petzold, A. Deutschbauer, J. D. Keasling

This study identifies bottlenecks in T3PKS product production in Pseudomonas putida and shows that deleting a catabolic enzyme increases bisdemethoxycurcumin yield.

Metabolic Engineering Communications · Jun 1, 2020Peer-reviewedMicrobiology

Characterization of an ECF56-family sigma factor from Streptomyces venezuelae reveals a highly conserved regulome

M. G. Thompson, A. Zargar, P. Cruz-Morales, T. De Rond, S. Chang, A. N. Pearson, G. Goyal, J. F. Barajas, J. M. Blake-Hedges, R. M. Phelan, V. Reyes-Umana, A. C. Hernandez, N. J. Hillson, P. M. Shih, J. D. Keasling

This study characterizes the ECF56-family sigma factor from Streptomyces venezuelae, showing its C-terminal extension is conserved and regulates a highly conserved regulome across Actinobacteria.

bioRxiv · Jan 30, 2020 · PreprintMicrobiology

Structural mechanism of regioselectivity in an unusual bacterial acyl-CoA dehydrogenase

J. M. Blake-Hedges, J. Henrique Pereira, P. Cruz-Morales, M. G. Thompson, J. F. Barajas, J. Chen, R. N. Krishna, L. J. G. Chan, D. Nimlos, C. Alonso-Martinez, E. Baidoo, Y. Chen, J. W. Gin, L. Katz, C. J. Petzold, , J. D. Keasling

This paper investigates the structural mechanism of regioselectivity in a bacterial acyl-CoA dehydrogenase, identifying key residues and structural features responsible for its unique substrate specificity.

bioRxiv · Oct 22, 2019Biochemistry

Massively parallel fitness profiling reveals multiple novel enzymes in Pseudomonas putida lysine metabolism

M. G. Thompson, J. M. Blake-Hedges, P. Cruz-Morales, J. F. Barajas, S. C. Curran, C. B. Eiben, N. C. Harris, V. T. Benites, J. W. Gin, W. A. Sharpless, F. F. Twigg, W. Skyrud, R. N. Krishna, J. H. Pereira, E. Baidoo, , J. D. Keasling

This paper uses RB-TnSeq to identify novel enzymes in Pseudomonas putida lysine metabolism, revealing new biochemical pathways and functions for DUF1338 proteins.

bioRxiv · Mar 18, 2019Microbiology