Author

J. M. Fulcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1

Frequent Co-Authors

L. Pasa-Tolic· 2 shared M. Zhou· 2 shared R. J. Moore· 2 shared W.-J. Qian· 2 shared A. C. Swensen· 1 shared A. E. Patterson· 1 shared A. J. Taylor· 1 shared A. Makaju· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

L. Pasa-Tolic

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Author profile →

3 papers

Recent·Most cited

Spatial top-down proteomics for the functional characterization of human kidney

K. J. Zemaitis, J. M. Fulcher, R. Kumar, D. J. Degnan, L. A. Lewis, Y.-C. Liao, M. Velickovic, S. M. Williams, R. J. Moore, L. M. Bramer, D. Velickovic, Y. Zhu, M. Zhou, L. Pasa-Tolic

This paper develops a spatial proteomics workflow to identify and map proteoforms in human kidney tissue, revealing spatially distinct proteomic profiles between glomeruli and tubules.

bioRxiv · Feb 13, 2024Biochemistry

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

Y.-C. Chen, A. J. Taylor, J. M. Fulcher, A. C. Swensen, X.-Q. Dai, M. Komba, K. L. C. Wrightson, K. Fok, A. E. Patterson, R. I. Klein-Geltink, P. E. MacDonald, W.-J. Qian, C. B. Verchere

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

bioRxiv · Oct 20, 2022 · PreprintPhysiology

Enhancing top-down proteomics of brain tissue with FAIMS

J. M. Fulcher, A. Makaju, R. J. Moore, M. Zhou, D. C. Bennett, P. L. De Jager, W.-J. Qian, L. Pasa-Tolic, V. A. Petyuk

This study shows that adding FAIMS to top-down proteomics improves proteome coverage in Alzheimer's brain tissue by doubling the number of non-redundant proteoforms identified.

bioRxiv · Jan 18, 2021Biochemistry