Author

P. E. MacDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 9 Cell Biology· 7 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 15 Research Focus:cell type annotation· 11 Organism:human· 11 Organism:mouse· 11 Research Focus:differential expression· 8 Approach:statistical model· 7 Assay:bulk RNA-seq· 6 Research Focus:cell signaling & trafficking· 6

Frequent Co-Authors

J. E. Manning Fox· 8 shared A. Bautista· 7 shared A. F. Spigelman· 7 shared N. Smith· 5 shared X.-Q. Dai· 5 shared H. Lin· 4 shared J. Camunas-Soler· 3 shared J. D. Johnson· 3 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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8 shared papersPhysiology

J. E. Manning Fox

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Author profile →

17 papers

Recent·Most cited

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

C. d. Santos, S. Shrestha, M. A. Cottam, G. Perkins, V. Lev-Ram, B. Roy, C. Acree, K.-Y. Kim, T. Deerinck, M. Cutler, D. Dean, J. P. Cartailler, P. E. MacDonald, M. W. Hetzer, M. H. Ellisman, R. Arrojo e Drigo

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

bioRxiv · Aug 23, 2023 · PreprintCell Biology

Complete Suspension Differentiation of Human Pluripotent Stem Cells into Pancreatic Islets Using Vertical-Wheel Bioreactors

N. Dadheech, M. Bermudez de Leon, N. Cuesta-Gomez, I. T. Jasra, R. Pawlick, B. Marfil-Garza, K. Verhoeff, S. Sapkota, H. Razavy, P. Anwar, J. Lyon, P. E. Macdonald, D. O' Gorman, G. Jickling, A. J. Shapiro

This study describes an all-stages complete suspension protocol for generating functional pancreatic islets from human pluripotent stem cells using Vertical Wheel bioreactors.

bioRxiv · Aug 9, 2023 · PreprintBioengineering

Pharmacological or genetic inhibition of Scn9a protects human and mouse beta cells while dampening insulin secretion in type 1 diabetes

P. Overby, A. G. Gordon, X.-Q. Dai, N. S. Nahirney, S. Provenzano, W. G. Sun, Y. Xia, J. A. Zhang, E. Panzhinskiy, C. M. J. Chu, H. H. Cen, S. Skovso, J. Kolic, A. G. Edwards, P. E. Macdonald, J. D. Johnson

This study shows that inhibiting Scn9a protects beta cells in type 1 diabetes by reducing excitability and improving survival, while also dampening insulin secretion.

bioRxiv · Jun 11, 2023 · PreprintPhysiology

Deletion of carboxypeptidase E in beta cells disrupts proinsulin processing and alters beta cell identity in mice

Y.-C. Chen, A. J. Taylor, J. M. Fulcher, A. C. Swensen, X.-Q. Dai, M. Komba, K. L. C. Wrightson, K. Fok, A. E. Patterson, R. I. Klein-Geltink, P. E. MacDonald, W.-J. Qian, C. B. Verchere

This study shows that deleting CPE in beta cells disrupts proinsulin processing and alters beta cell identity, leading to impaired function and increased beta-cell area in mice.

bioRxiv · Oct 20, 2022 · PreprintPhysiology

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

K. K. Mattis, N. A. J. Krentz, C. Metzendorf, F. Abaitua, A. F. Spigelman, H. Sun, A. K. Rottner, A. Bautista, E. Mazzaferro, M. Perez-Alcantara, J. E. Manning Fox, J. M. Torres, A. Weslowska-Andersen, G. Z. Yu, A. Mahajan, , A. L. Gloyn

This study shows that loss of RREB1 in beta cells reduces insulin content and affects gene expression, linking RREB1 to diabetes risk through its role in beta cell function and development.

bioRxiv · Jun 4, 2022Physiology

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

T. A. Alghamdi, N. A. J. Krentz, N. Smith, A. F. Spigelman, V. Rajesh, A. Jha, M. Ferdaoussi, J. E. Manning Fox, H. Sun, Z. Sun, A. L. Gloyn, P. E. MacDonald

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

bioRxiv · May 18, 2022Physiology

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

H. Lin, K. Suzuki, N. Smith, X. Li, L. Nalbach, S. Fuentes, A. F. Spigelman, X.-Q. Dai, A. Bautista, M. Ferdaoussi, S. Aggarwal, A. R. Pepper, L. P. Roma, E. Ampofo, W.-h. Li, P. E. MacDonald

This study identifies SENP1's role in β-cell redox sensing during high-fat feeding, showing its requirement for enhanced exocytosis and glucose intolerance.

bioRxiv · Apr 5, 2022Cell Biology

Impacts of the COVID-19 Pandemic on a Human Research Islet Program

T. J. Dafoe, T. dos Santos, A. F. Spigelman, J. Lyon, N. Smith, A. Bautista, P. E. MacDonald, J. E. Manning Fox

This study examines how the COVID-19 pandemic affected islet processing and distribution at a human research islet facility, finding reduced organ processing but maintained islet quality, though recipient feedback was poorer due to longer transit times.

bioRxiv · Dec 24, 2021Physiology

Ca2+ oscillations, waves, and networks in islets from human donors with and without type 2 diabetes

M. Gosak, R. Yan-Do, H. Lin, P. E. Macdonald, A. Stozer

This study uses calcium imaging to compare calcium oscillations, waves, and network dynamics in human islets from donors with and without type 2 diabetes, finding altered glucose responses and network structure in diabetic islets.

bioRxiv · Dec 8, 2021Physiology

Pharmacologic rescue of circadian β-cell failure through P2Y1 purinergic receptor identified by small-molecule screen

J. Bass, B. Marcheva, B. J. Weidemann, A. Taguchi, M. Perelis, K. M. Ramsey, M. V. Newman, Y. Kobayashi, C. Omura, J. E. Manning Fox, H. Lin, P. E. Macdonald

The paper identifies the P2Y1 purinergic receptor as a target to rescue circadian β-cell failure using a small-molecule screen and validates ivermectin as a glucose-dependent secretagogue.

bioRxiv · Nov 5, 2021Cell Biology

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

X.-Q. Dai, J. Camunas-Soler, L. J. Briant, T. dos Santos, A. F. Spigelman, E. M. Walker, R. Arrojo e Drigo, A. Bautista, R. C. Jones, J. Lyon, A. Nie, N. Smith, J. E. Manning Fox, S. K. Kim, P. Rorsman, , P. E. MacDonald

This study identifies heterogeneous α-cell dysfunction in type 2 diabetes linked to impaired maturation and electrophysiological changes.

bioRxiv · Apr 8, 2021Cell Biology

A new hypothesis for type 1 diabetes risk: The at-risk allele at rs3842753 associates with increased beta cell INS mRNA in a meta-analysis of single cell RNA sequencing data

S. Wang, S. Flibotte, J. Camunas-Soler, P. E. MacDonald, J. D. Johnson

This study finds that the rs3842753 C allele is associated with higher INS mRNA and ER stress in beta cells, suggesting a link between genetic variation and beta cell dysfunction in type 1 diabetes.

bioRxiv · Dec 6, 2020Cell Biology

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

H. Lin, N. Smith, A. F. Spigelman, K. Suzuki, M. Ferdaoussi, Y. Jin, A. Bautista, Y. W. Wang, J. E. Manning Fox, J. Buteau, P. E. MacDonald

This study shows that β-cell SENP1 improves insulin secretion in response to incretins and reduces oral glucose intolerance in high-fat-fed mice.

bioRxiv · Nov 30, 2020Physiology

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

S. Skovso, E. Panzhinskiy, J. Kolic, H. H. Cen, D. A. Dionne, X.-Q. Dai, R. B. Sharma, L. Elghazi, C. E. Ellis, K. Faulkner, S. A. M. Marcil, P. Overby, N. Noursadeghi, D. Hutchinson, X. Hu, , J. D. Johnson

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

bioRxiv · Oct 15, 2020Physiology

NFIA regulates granule recruitment and exocytosis in the adult pancreas

M. A. Scavuzzo, J. Chmielowiec, J. Teaw, D. Yang, M. C. Hill, A. R. Waksmunski, L. Duraine, J. Camunas-Soler, X. Dai, J. C. King, S. R. Quake, P. E. MacDonald, A. Catic, M. Borowiak

This study identifies NFIA as a regulator of granule recruitment and exocytosis in pancreatic cells, showing its role in insulin and enzyme secretion and linking it to metabolic disorders.

bioRxiv · Dec 24, 2019 · PreprintCell Biology

Vitamin D-binding protein is required for the maintenance of α-cell function and glucagon secretion

K. Viloria, D. Nasteska, L. J. B. Briant, S. Helsing, D. Larner, N. H. F. Fine, F. B. Ashford, G. da Silva Xavier, M. Jimenez Ramos, J. E. Manning Fox, P. E. MacDonald, I. Akerman, G. G. Lavery, C. Flaxman, N. G. Morgan, , D. J. Hodson

This study shows that vitamin D-binding protein (DBP) is essential for maintaining β-cell function and glucagon secretion, with reduced DBP expression observed in late-onset type 1 diabetes.

bioRxiv · Dec 19, 2019 · PreprintPhysiology

A glucose-dependent spatial patterning of exocytosis inhuman β-cells is disrupted in type 2 diabetes

J. Fu, J. M. Githaka, X. Dai, G. Plummer, K. Suzuki, A. F. Spigelman, A. Bautista, R. Kim, D. Greitzer-Antes, J. E. Manning Fox, H. Y. Gaisano, P. E. MacDonald

This study shows that glucose-dependent spatial organization of exocytosis in human β-cells is disrupted in type 2 diabetes.

bioRxiv · May 3, 2019Cell Biology