R. A. Britton

Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly

The paper identifies 25 rRNA modification sites in B. subtilis and links them to RbgA-dependent large subunit assembly.

Microbial stimulation of oxytocin release from the intestinal epithelium via secretin signaling

This study identifies oxytocin as an intestinal hormone produced and secreted by enterocytes in response to secretin stimulation by L. reuteri.

Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model

This study evaluates a humanized microbiota mouse model to understand how vaginal microbiota composition influences susceptibility to urogenital pathogens, finding that certain bacterial taxa correlate with reduced pathogen levels but show inconsistent in vitro and in vivo effects.

Separation of the effects of small intestinal microbiome-diet interactions on human gut hormone secretion

The paper introduces a platform called CAMIO to study how small intestinal microbiome-diet interactions affect gut hormone secretion, finding differential secretion of ghrelin, PP, and PYY based on dietary sugars.

AMiGA: software for automated Analysis of Microbial Growth Assays

AMiGA automates the analysis of microbial growth assays, estimating growth parameters and testing differential growth without assuming growth curve shapes.

Identification of simplified microbial communities that inhibit Clostridioides difficile infection through dilution/extinction

The paper identifies simplified microbial communities that inhibit C. difficile infection through dilution/extinction and tests their efficacy in a mouse model.

Rotavirus Induces Intercellular Calcium Waves Through ADP Signaling

This study shows rotavirus induces intercellular calcium waves via ADP signaling, which amplifies diarrheal symptoms and can be blocked by P2Y1 antagonists or knockout.

Degradation of the incretin hormone Glucagon-Like Peptide-1 (GLP-1) by Enterococcus faecalis metalloprotease GelE

This study identifies Enterococcus faecalis protease GelE as a factor that degrades the incretin hormone GLP-1, potentially impacting glucose homeostasis and metabolic disease.

Human intestinal enteroids with inducible neurogenin-3 expression as a novel model of gut hormone secretion

This paper develops a method to increase enteroendocrine cells in human intestinal enteroids using inducible neurogenin-3 expression, enabling functional studies of gut hormone secretion.

A novel human enteroid-anaerobe co-culture system to study microbial-host interaction under physiological hypoxia

This paper introduces a co-culture system to study host-microbe interactions under physiological hypoxia using human intestinal enteroids and anaerobic bacteria.

Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease

The paper identifies a bacterial peptide, GspA from Staphylococcus epidermidis, that stimulates GLP-1 secretion and reduces obesity and T2DM markers in mice.

Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

This study shows that small intestinal lactobacilli can resist the toxicity of soybean oil fatty acids through environmental protection and evolutionary adaptation.