A. A. Dandekar

Widespread fungal-bacterial competition for magnesium enhances antibiotic resistance

Fungi sequester magnesium from bacteria, reducing their fitness but increasing antibiotic resistance to colistin.

Tripartite interactions between filamentous Pf4 bacteriophage, Pseudomonas aeruginosa, and bacterivorous nematodes

This study shows that curing Pseudomonas aeruginosa of Pf4 phage infection increases virulence in C. elegans by enhancing PQS quorum sensing and pyocyanin production, but nematodes unable to detect bacterial pigments are more susceptible to the Pf4-cured strain.

Genetic and transcriptomic characteristics of RhlR-dependent quorum sensing in cystic fibrosis isolates of Pseudomonas aeruginosa

The paper examines genetic and transcriptomic features of RhlR-dependent quorum sensing in Pseudomonas aeruginosa isolates from cystic fibrosis patients, identifying a core regulon and highlighting the importance of RhlR in chronic infections.

Evolution of the quorum sensing regulon in cooperating populations of Pseudomonas aeruginosa

The paper shows that long-term growth of Pseudomonas aeruginosa under limited QS conditions reduces the number of QS-activated genes by 45-70%.

Tobramycin adaptation enhances policing of social cheaters in Pseudomonas aeruginosa

This study shows tobramycin suppresses lasR mutants in Pseudomonas aeruginosa by directly targeting cheaters and selecting for mutations that enhance pyocyanin-mediated policing.

Burkholderia thailandensis methylated hydroxy-alkylquinolines: biosynthesis and antimicrobial activity in co-culture experiments

This study identifies N-oxidated methyl-alkenylquinolines (HMAQ-NOs) as antimicrobial compounds produced by Burkholderia thailandensis, showing they are 50-fold more active than their non-oxidized counterparts against Bacillus subtilis.

Non-hierarchical, RhlR-regulated acyl-homoserine lactone quorum sensing in a cystic fibrosis isolate of Pseudomonas aeruginosa

The paper shows that a LasR-null Pseudomonas aeruginosa isolate uses RhlR for quorum sensing and virulence, suggesting RhlR as a therapeutic target in chronic infections.