Author

J. Merritt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 4 Assay:proteomics· 3 Organism:bacteria (other)· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:E. coli· 1

Frequent Co-Authors

J. Kreth· 3 shared D. Anderson· 2 shared E. A. Palmer· 2 shared H. Qin· 2 shared M. Krieger· 2 shared S. McGuire· 2 shared Z. Zou· 2 shared A. Yoo· 1 shared

Activity by Year

2016-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMicrobiology

J. Kreth

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The prevalence of Fusobacterium nucleatum subspecies in the oral cavity stratifies by local health status

M. Krieger, Y. M. AbdelRahman, D. Choi, E. A. Palmer, A. Yoo, S. McGuire, J. Kreth, J. Merritt

This study investigates the prevalence of Fusobacterium nucleatum subspecies in the oral cavity and finds that their distribution varies with local health status.

bioRxiv · Oct 25, 2023 · PreprintMicrobiology

Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans

H. Qin, D. Anderson, Z. Zou, D. Higashi, C. Borland, J. L. Kreth, J. Merritt

The paper identifies the MecA interactome of Streptococcus mutans using mass spectrometry and split luciferase complementation assays, revealing both Clp-dependent and proteolysis-independent regulatory mechanisms.

bioRxiv · Sep 8, 2023 · PreprintMicrobiology

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

M. Kathiresan, S. Animesh, R. Morris, J. Kreuzer, P. Krushna, L. Shi, J. Merritt, X. Yin, C. H. Benes, N. Bardeesy, W. Haas

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

bioRxiv · May 4, 2023 · PreprintCancer Biology

Identification of novel PGRP3 protein -protein interactions using yeast two hybrid system

L.-j. Lin, C. Lee, J. Merritt, J. Kreth, S. Ranganathan, S. Prakasam

This study identifies and validates two novel PGRP3-interacting proteins, MBNL3 and RBP5, using yeast two-hybrid screening and co-immunoprecipitation.

bioRxiv · Dec 16, 2022 · PreprintImmunology

Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease

D. L. Higashi, S. McGuire, Y. Abdelrahman, Z. Zou, H. Qin, D. Anderson, E. A. Palmer, J. Kreth, J. Merritt

This paper develops the first genetic system for Parvimonas micra, enabling molecular studies of its role in disease.

bioRxiv · Jan 27, 2022Microbiology

Genome-wide identification of novel sRNAs in Streptococcus mutans

M. Krieger, J. Merritt, R. Raghavan

This study identifies 15 novel sRNAs in Streptococcus mutans that respond to stress conditions and shows one sRNA, SmsR4, regulates sorbitol transport.

bioRxiv · Nov 16, 2021Microbiology

Environment determines evolutionary trajectory in a constrained phenotypic space

D. T. Fraebel, H. Mickalide, D. Schnitkey, J. Merritt, T. E. Kuhlman, S. Kuehn

The paper shows that environmental constraints shape evolutionary trajectories in Escherichia coli by mediating trade-offs between swimming speed and growth rate through antagonistic pleiotropy.

bioRxiv · Dec 27, 2016Evolutionary Biology