Z. Zou

Dihydrothiazolo ring-fused 2-pyridone antimicrobial compounds treat Streptococcus pyogenes skin and soft tissue infection

This study develops and tests GmPcides, dihydrothiazolo ring-fused 2-pyridone compounds, showing efficacy against Streptococcus pyogenes SSTI and biofilm formation.

Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans

The paper identifies the MecA interactome of Streptococcus mutans using mass spectrometry and split luciferase complementation assays, revealing both Clp-dependent and proteolysis-independent regulatory mechanisms.

Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores

This study identifies enterobactin and its catabolites as functional siderophores in UPEC, showing incomplete hydrolysis allows for multiple iron acquisitions per molecule.

Elucidating disease-associated mechanisms triggered by pollutants via the epigenetic landscape using large-scale ChIP-Seq data

The paper introduces DAR-ChIPEA, a method using ChIP-Seq data to identify TFs involved in pollutant-induced epigenetic changes, outperforming previous methods in predicting disease mechanisms.

CDKL5 regulates p62-mediated selective autophagy and host antiviral defense

This study identifies CDKL5 as a regulator of virophagy, showing it promotes p62-mediated autophagy of viral capsids and enhances antiviral defense.

Bioinformatics analysis of immune-related prognostic genes and immunotherapy in renal clear cell carcinoma

The paper identifies 4 immunoprognostic genes in ccRCC using bioinformatics analysis of public databases and validates their association with prognosis and immunotherapy response.

Important Role of Hematopoietic Proteoglycan Serglycin in Liver Hepatocellular Carcinoma Associated with Tumor Microenvironment

This study investigates the role of Serglycin in liver hepatocellular carcinoma, showing its association with tumor microenvironment and prognosis.

The mechanism underlying redundant functions of the YTHDF proteins

This study investigates the redundant functions of YTHDF proteins, showing that YTHDF1 and YTHDF2 have distinct roles in RNA decay and condensate formation, and that RNA stabilization after YTHDF depletion is m6A-independent.

Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease

This paper develops the first genetic system for Parvimonas micra, enabling molecular studies of its role in disease.

BECN1 F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

This study shows that the Becn1F121A mutation enhances autophagic flux in aged mice, improving aging phenotypes in some organs but not others.

Enhanced soil quality after forest conversion to vegetable cropland and tea plantation has contrasting effects on soil microbial structure and functions

This study examines how soil quality changes after forest conversion to vegetable cropland and tea plantations, showing contrasting effects on microbial community structure and functions.

Pathogenic potential in catheter associated Escherichia coli is associated with separable biofilm and virulence gene determinants

This study identifies distinct genetic determinants for biofilm formation and virulence in E. coli associated with catheter-related infections.

SARS-CoV-2 neutralizing serum antibodies in cats: a serological investigation

The paper investigates SARS-CoV-2 infection in cats by detecting serum antibodies, finding 14.7% of post-outbreak samples positive for RBD and 11 with neutralizing antibodies.

Three-dimensional Structural Interrelations between Cells, Extracellular Matrix and Mineral in Vertebrate Mineralization

This paper uses 3D imaging to study the structural relationships between cells, extracellular matrix, and mineral in avian tendons, revealing a new mechanism for mineralization involving interfibrillar transport of ions and mineral precursors.

Deep residual neural networks resolve quartet molecular phylogenies

This study uses deep residual neural networks to infer four-taxon phylogenies, outperforming existing methods under substitution heterogeneities.

Cloning human dental pulp cells and studying inter-clone diversity

The paper clones human dental pulp cells to study inter-clone diversity and improves reliability of single-cell origin through a 96-well plate method.