Author

C. H. Benes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Amzallag· 1 shared A. C. Faber· 1 shared A. D. Sahu· 1 shared A. Dastur· 1 shared A. Friedman· 1 shared A. K. Yu· 1 shared A. L. Burlingame· 1 shared A. Tam· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Amzallag

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Author profile →

4 papers

Recent·Most cited

Protein interactome homeostasis through an N-recognin E3 ligase is a vulnerability in aneuploid cancer

M. Kathiresan, S. Animesh, R. Morris, J. Kreuzer, P. Krushna, L. Shi, J. Merritt, X. Yin, C. H. Benes, N. Bardeesy, W. Haas

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

bioRxiv · May 4, 2023 · PreprintCancer Biology

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

S. Jacob, T. H. Turner, J. Cai, K. V. Floros, A. K. Yu, C. M. Coon, R. Khatri, M. A. Alzubi, C. T. Jakubik, Y. M. Bouck, M. Puchalapalli, M. Shende, M. G. Dozmorov, S. Boikos, B. Hu, , A. C. Faber

The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.

bioRxiv · May 17, 2022Cancer Biology

A landscape of synergistic drug combinations in non-small-cell lung cancer

N. U. Nair, P. Greninger, A. Friedman, A. Amzallag, E. Cortez, A. D. Sahu, J. S. Lee, A. Dastur, R. K. Egan, E. Murchie, G. S. Crowther, J. McClanaghan, J. Boisvert, L. Damon, J. Ho, , C. H. Benes

The paper identifies synergistic drug combinations in non-small-cell lung cancer cell lines, finding that synergy often arises from sensitizing resistant models through dual pathway targeting.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRAS

A. Urisman, T. L. Yuan, M. Trinidad, J. H. Morris, S. Afghani, J. A. Oses-Prieto, C. D. Ritchie, M. S. Zahari, C. H. Benes, A. L. Burlingame, F. McCormick

This study uses targeted phosphoproteomics to analyze KRAS signaling network regulation in lung cancer cells, identifying unique phosphorylation changes and their roles in transcriptional silencing.

bioRxiv · Jul 9, 2019 · PreprintCancer Biology