Author

T. Flock

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Morales-Pastor· 1 shared A. Rufer· 1 shared B. Plouffe· 1 shared C. Le Gouill· 1 shared C.-J. Tsai· 1 shared D. Veprintsev· 1 shared F. Heydenreich· 1 shared F. Pamula· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCell Biology

A. Morales-Pastor

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Author profile →

2 papers

Recent·Most cited

Multiple triggers converge to preferential effector coupling in the CB2R through a complex allosteric communication network

A. Morales-Pastor, T. Miljus, T. M. Stepniewski, V. Ledesma, F. Heydenreich, T. Flock, B. Plouffe, C. Le Gouill, J. Duchaine, W. Guba, A. Rufer, U. Grether, M. Bouvier, D. Veprintsev, J. Selent

The paper investigates how multiple triggers on an allosteric communication network influence preferential coupling of the CB2R to Gi2 over β-arrestin1, revealing insights into GPCR signaling mechanisms.

bioRxiv · Feb 27, 2024 · PreprintCell Biology

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit

C.-J. Tsai, J. Marino, R. J. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. M. Taylor, I. Mohammed, H. Matile, R. J. Dawson, X. Deupi, H. Stahlberg, G. F. Schertler

The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.

bioRxiv · Feb 12, 2019Biochemistry