I. Mohammed

Low-dose cryo-electron ptychography of proteins at sub-nanometer resolution

This paper applies low-dose cryo-EM and 4D-STEM ptychography to achieve sub-nanometer resolution 3D reconstructions of frozen hydrated proteins.

Structural basis of adenylyl cyclase 9 activation

The paper presents cryo-EM structures of AC9 in different states to reveal activator-induced conformational changes essential for its activation.

Catalytic cycling of human mitochondrial Lon protease

This study characterizes the mechanism of human mitochondrial LonP1 protease using cryo-EM, revealing its conformational states and a new proteolytic center.

Evaluation of Host Defense Peptide (CaD23)-Antibiotic Interaction and Mechanism of Action: Insights from Experimental and Molecular Dynamics Simulations Studies

This study evaluates the synergistic interaction of CaD23 with antibiotics and identifies its membrane-permeabilizing mechanism through experimental and molecular dynamics simulations.

Hybrid Derivative of Cathelicidin and Human Beta Defensin-2 Against Gram-Positive Bacteria: A Novel Approach for the Treatment of Bacterial Keratitis

This paper develops a hybrid antimicrobial peptide (CaD23) from human-derived host defense peptides, showing high efficacy against Gram-positive bacteria and reduced antimicrobial resistance compared to amikacin.

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

This paper introduces a microfluidic method for isolating and preparing proteins for cryo-EM, enabling high-resolution structure determination from minimal cell lysate.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit

The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.