S. Maeda

Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

The paper presents the structure of yeast CPT1 in multiple substrate-bound states to elucidate the mechanism of phospholipid synthesis and selectivity.

Selective plane activation structured illumination microscopy

This study improves structured illumination microscopy by using selective plane illumination and photoswitchable proteins to eliminate out-of-focus background, enabling high-resolution imaging of volumetric samples.

The Nse5/6-like SIMC1-SLF2 Complex Localizes SMC5/6 to Viral Replication Centers

This paper identifies SIMC1 and SLF2 as novel subunits forming Nse5/6-like complexes that regulate SMC5/6 localization to viral replication centers and DNA damage sites.

CCR4 blockade leads to clinical activity and prolongs survival in a canine model of advanced prostate cancer

The paper shows that blocking CCR4 reduces Treg infiltration and improves survival in a canine model of advanced prostate cancer.

The dynamics of cell-free DNA from urine and blood after a full marathon

This study examines changes in serum and urinary cfDNA levels and fragment sizes after a full marathon, showing transient increases and size variations.

First and broad detection of three typical carbapenemase genes on the surfaces of commercially available spices worldwide and isolation of complete NDM-1 genes from black pepper, cumin, and clove

Circulating Th17.1 cells as candidate for prediction of therapeutic response to abatacept in patients with rheumatoid arthritis: exploratory research

This study identifies Th17.1 cells as a biomarker predicting response to abatacept in rheumatoid arthritis patients.

The autophagic membrane tether ATG2A transfers lipids between membranes

This study identifies ATG2A as a lipid-transfer protein that facilitates phagophore expansion by transferring lipids from the ER to the phagophore.

Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the Gβ subunit

The paper presents a cryo-EM structure of the rhodopsin-Gαi-βγ complex, revealing the C-terminal tail of rhodopsin bound to the Gβ subunit and identifying common anchoring points across G protein-subtype interactions.

Local membrane charge regulates β2 adrenergic receptor coupling to Gi

This study shows that local membrane charge affects β2AR coupling to Gi and Gs proteins, with negative charges inhibiting Gi coupling and promoting Gs coupling.