Author

J. Muller-Greven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

M. Buck· 2 shared A. Brewer· 1 shared A. Weinberg· 1 shared B. Jastrzebska· 1 shared D. Adams· 1 shared J. Ortega· 1 shared J. Penfield· 1 shared J. Scott-McKean· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

M. Buck

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Author profile →

2 papers

Recent·Most cited

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

S. Matsuyama, M. Matsuyama, J. Ortega, Y. Fedorov, J. Scott-McKean, J. Muller-Greven, M. Buck, D. Adams, B. Jastrzebska, W. Greenlee

The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.

bioRxiv · Oct 12, 2022 · PreprintCell Biology

Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells

L. Zhang, S. K. Ghosh, S. C. Basavarajappa, J. Muller-Greven, J. Penfield, A. Brewer, P. Ramakrishnan, M. Buck, A. Weinberg

The paper shows hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2-expressing cells, with a KD of ~300 nM and IC50 of 2.4 μM.

bioRxiv · Jan 7, 2021 · PreprintBiochemistry