S. Matsuyama

Development of novel cytoprotective small compounds inhibiting mitochondria-dependent apoptosis

The paper identifies and develops M109S, a small molecule that inhibits mitochondria-dependent apoptosis in various cell types and models.

Use of the particle agglutination/particle agglutination-inhibition test for antigenic analysis of SARS-CoV-2

This study develops a PA/PAI test to rapidly assess SARS-CoV-2 antigenicity using hACE2-bound latex beads, showing it can detect antigenic differences between variants.

Female reproductive dormancy in Drosophila melanogaster is regulated by DH31-producing neurons projecting into the corpus allatum

This study identifies DH31-producing neurons projecting to the corpus allatum as essential for regulating reproductive dormancy in Drosophila by suppressing juvenile hormone biosynthesis.

The inhaled steroid ciclesonide blocks SARS-CoV-2 RNA replication by targeting viral replication-transcription complex in culture cells

This paper identifies ciclesonide as an inhaled corticosteroid that inhibits SARS-CoV-2 replication by targeting the viral replication-transcription complex in cultured cells.

Nelfinavir inhibits replication of severe acute respiratory syndrome coronavirus 2 in vitro.

This study shows nelfinavir, an HIV-1 protease inhibitor, potently inhibits SARS-CoV-2 replication in vitro with EC50 and EC90 values lower than lopinavir.

The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15

The paper identifies ciclesonide as a corticosteroid that inhibits coronavirus replication by targeting NSP15, with resistance emerging through an amino acid substitution.