S. K. Ghosh

Evidence of 14-3-3 proteins contributing to kinetochore integrity and chromosome congression during mitosis

This study shows that 14-3-3 proteins in yeast are essential for kinetochore integrity and proper chromosome segregation during mitosis.

Non-essential kinetochore proteins contribute to meiotic chromosome condensation through polo-like kinase

The paper investigates the role of non-essential kinetochore proteins in meiotic chromosome condensation and finds that Ctf19 influences condensation by modulating Cdc5 activity and condensin stability.

Redefining the structure of tip-links in hair-cells

The paper redefines the structure of tip-links in hair-cells by showing cadherin-23 forms trans-homodimers rather than cis-dimers, while protocadherin-15 remains as cis-dimers.

Evidence of kinesin motors involved in stable kinetochore assembly during early meiosis

This study identifies kinesin motors involved in stable kinetochore assembly during early meiosis in budding yeast.

Template-Directed RIG-I Agonist Assembly for Targeted Cancer Immunotherapy

This paper develops a tumor-selective RIG-I agonist that induces type-I IFN signaling and tumor cell apoptosis through template-directed assembly using miRNA-21.

Insights into the microevolution of SARS-ACE2 Interactions: In-silico analysis of glycosylation and SNP pattern

The paper analyzes the microevolution of SARS-CoV-2 by examining glycosylation and SNP patterns to understand changes in SARS-ACE2 interactions and their impact on viral binding affinity.

Transient interactions drive the lateral clustering of Cadherin-23 on membrane

This study shows that transient hydrophobic interactions drive lateral clustering of cadherin-23 on membranes, enhancing cell adhesion without requiring specific cis-dimer interactions.

Molecular dynamics simulations and functional studies reveal that hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2 expressing cells

The paper shows hBD-2 binds SARS-CoV-2 spike RBD and blocks viral entry into ACE2-expressing cells, with a KD of ~300 nM and IC50 of 2.4 μM.

Shugoshin promotes efficient activation of spindle assembly checkpoint and timely spindle disassembly

This study identifies a novel role of Sgo1 in facilitating spindle disassembly and maintaining the spindle assembly checkpoint in Candida albicans.

Hitchhiking on condensed chromatin promotes plasmid persistence in yeast without perturbing chromosome function

The paper shows yeast plasmids persist by hitchhiking on condensed chromatin near telomeres, without disrupting chromosome function.

Novel insights into Entamoeba cyst wall formation and the importance of actin cytoskeleton

This study investigates the morphological stages of chitin wall formation in Entamoeba invadens, revealing the role of chitin synthase and actin cytoskeleton dynamics in cyst wall development.

Stress-responsive Entamoeba topoisomerase II: a potential anti-amoebic target

This paper identifies a stress-responsive topoisomerase II in Entamoeba histolytica that shows potential as an antiamoebic target due to its differential sensitivity to drugs compared to human cells.

Polarized Entamoeba: A model for stable bleb driven motility

Pentoxifylline induces a stable bleb-driven polarized morphology in Entamoeba, enhancing directional motility and chemotaxis by inhibiting adenosine receptor activity.

Unique PKD like protein kinase in Entamoeba histolytica regulates vital actin mediated processes

This study identifies and characterizes EhPKDL, a PKD-like protein kinase in Entamoeba histolytica that nucleates actin polymerization and is essential for actin-mediated processes like erythrophagocytosis.

Anti-cancer property of Lenzites betulina (L) Fr. on cervical cancer cell lines and its anti-tumor effect on HeLa-implanted mice

This study evaluates the anti-cancer properties of Lenzites betulina extract on cervical cancer cell lines and in mice, showing significant cell inhibition and tumor reduction.

How epigenome drives chromatin folding and dynamics, insights from efficient coarse-grained models of chromosomes

The paper develops efficient coarse-grained models to simulate chromosome dynamics and shows they reproduce experimental data and predict dynamic chromatin motion during the cell cycle.